Objective To explore the levels and significance of serum N-terminal pro-brain natriuretic pep-tide(NT-pro-BNP),insulin-like growth factor binding protein-7(IGFBP-7)and C1q tumor necrosis factor re-lated protein 12(CTRP12)in the patients with chronic heart failure(CHF).Methods A total of 116 CHF patients receiving treatment in this hospital from October 2019 to March 2021 were selected as the CHF group.The patients were classified into the grade Ⅱ(47 cases),grade Ⅲ(41 cases),and grade Ⅳ(28 cases)according to the New York Heart Association(NYHA)cardiac function grading.Sixty-four healthy individu-als undergoing physical examinations in this hospital during the same period were selected as the control group.CHF group and control group of left ventricular end diastolic diameter(LVEDD),left ventricular ejec-tion fraction(LVEF)and serum NT-pro-BNP,IGFBP-7and CTRP12 levels were detected and compared.Ac-cording to the occurrence of major adverse cardiac events(MACE)in CHF patients within one year after dis-charge,they are divided into the MACE group and non MACE group.The clinical data were compared between the MACE group and non MACE group and analyzed.The multivariate Logistic regression was drawing to an-alyze the influencing factors of MACE occurrence in CHF patients,and the receiver operating characteristic(ROC)curve was used to analyze the efficiency of serum NT-pro-BNP,IGFBP-7,CTRP12 in predicting MACE occurrence in CHF patients.Results Compared with the control group,the LVEF and serum CTRP12 level in the CHF group were decreased,LVEDD was increased,serum NT-pro-BNP,IGFBP-7,Hcy and hs-CRP levels were increased,and the differences were statistically significant(P＜0.05).In the patients with different grades of CHF,serum NT-pro-BNP,IGFBP-7,Hcy,hs-CRP levels and LVEDD all were the grade Ⅱpatients＜grade Ⅲ patients＜grade Ⅳ patients,the serum CTRP12 level and LVEF were the grade Ⅱ pa-tients＞grade Ⅲ patients＞grade Ⅳ patients,and the comparison between any two levels showed statistical-ly significant difference(P＜0.05).Compared with non-MACE group,the LVEF and serum CTRP12 level in the MACE group were decreased,LVEDD was increased,serum Hcy,hs-CRP,NT-pro-BNP and IGFBP-7 lev-els were increased,and the differences were statistically significant(P＜0.05).The multivariate Logistic re-gression analysis results showed that serum NT-pro-BNP,IGFBP-7 and CTRP12 levels were the influencing factors for MACE occurrence in CHF patients(P＜0.05).The ROC curve analysis results showed that the area under the curve(AUC)of serum NT-pro-BNP,IGFBP-7,CTRP12 alone and three combination for pre-dicting MACE occurrence in CHF patients were 0.862(95％CI:0.786-0.919),0.805(95％CI:0.721-0.872),0.860(95％CI:0.784-0.918)and 0.961(95％CI:0.908-0.988),respectively.AUC of the three-i-tem-combination prediction was significantly higher than that of the independent predictions of NT-pro-BNP,IGFBP-7 and CTRP12(Z=3.050,3.883 and 3.218,all P＜0.05).Conclusion The levels of serum NT-pro-BNP and IGFBP-7 in CHF patients are increased,while the serum CTRP12 level is decreased,moreover the levels of NT-pro-BNP,IGFBP-7 and CTRP12 change with the grading of cardiac function.The 3-item com-bined detection has better efficiency in predicting MACE occurrence in CHF patients.
chronic heart failureN-terminal pro-brain natriuretic peptideinsulin like growth factor binding protein-7C1q tumor necrosis factor associated protein 12major adverse cardiac event
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