Predictive value of serum AIM2 and CDC42 combined detection for MACE in patients with acute myocardial infarction
Objective To analyze the predictive value of serum melanoma deficiency factor 2(AIM2)and cell division cyclin 42(CDC42)in the occurrence of major adverse cardiovascular events(MACE)in patients with acute myocardial infarction(AMI).Methods A total of 108 patients with AMI who underwent percuta-neous coronary intervention in Beijing Aerospace General Hospital from February 2019 to December 2021 were included in AMI group,and 60 healthy people who underwent physical examination in Beijing Aerospace General Hospital during the same period were selected as control group.Baseline data of patients were collect-ed,serum AIM2 and CDC42 levels were detected by Enzyme-linked immunosorbent assay,and AMI patients were followed up for 6 months.According to whether MACE occurred during the follow-up period,they were divided into MACE group and non-MACE group.Spearman correlation was used to analyze the correlation be-tween levels of serum AIM2,CDC42 and Killip grade of cardiac function in AMI patients.Multivariate Logistic regression was used to analyze the influencing factors of MACE in patients with AMI.Receiver operating char-acteristic(ROC)curve was plotted to analyze the predictive value of serum AIM2 and CDC42 for MACE alone and in combination in AMI patients.Results The level of AIM2 in AMI group was higher than that in control group,and the level of CDC42 in AMI group was lower than that in control group,and the differences were statistically significant(P＜0.05).There were 29 patients in the MACE group and 79 patients in the non-MACE group.The serum AIM2 level in MACE group was higher than that in non-MACE group,and the ser-um CDC42 level in MACE group was lower than that in non-MACE group,with statistical significance(P＜0.05).Compared with Killip grade Ⅰ-Ⅱ AMI patients,the serum AIM2 level in Killip grade Ⅲ-Ⅳ AMI patients was higher and the CDC42 level was lower,with statistical significance(P＜0.05).Spearman correla-tion analysis showed that serum AIM2 level was positively correlated with Killip grade of cardiac function in AMI patients(rs=0.667,P＜0.001),and serum CDC42 level was negatively correlated with Killip grade of cardiac function(rs=-0.712,P＜0.001).Multivariate Logistic regression analysis showed that the increase of serum AIM2 level was an independent risk factor for MACE in AMI patients,and the increase of serum CDC42 level was a protective factor for MACE in AMI patients(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of AIM2 and CDC42 combined predicted MACE in AMI patients was 0.901,which was higher than the AUC of AIM2 and CDC42 alone(Z=4.886 and 4.269,P＜0.001).Conclusion Serum AIM2 level increased and CDC42 level decreased in patients with AMI,both of which are correlated with Killip grade of cardiac function in patients with AMI.Serum AIM2 and CDC42 combined de-tection has a high predictive value for MACE occurrence in patients with AMI.
万方数据
维普
