Advances in laboratory detection techniques for multidrug-resistant tuberculosis
Multidrug-resistant tuberculosis(MDR-TB)refers to tuberculosis that is resistant to at least two first-line anti-tuberculosis drugs including isoniazid and rifampicin,which seriously threatens human health and life.Therefore,early and rapid detection of drug resistance is the key to effective treatment of MDR-TB patients.At present,the clinical diagnosis of MDR-TB is mainly based on phenotypic drug sensitivity test(pDST),but pDST takes a long time,which delays the best treatment opportunity for patients to some extent,while genotypic drug sensitivity test(gDST)can complete drug resistance detection in a short time.At present,in the research of MDR-TB diagnosis,pDST detection combined with gDST detection is a research hotspot,but it is still in the exploratory stage,lacking of multicenter,large sample and prospective research re-ports.In this paper,the laboratory detection techniques of MDR-TB are reviewed,in order to make readers deeply understand the diagnosis status and future research direction of MDR-TB and provide reference for the rapid diagnosis and treatment of MDR-TB.
tuberculosismultidrug resistancedetectionphenotypic drug sensitivity testgeno-typic drug sensitivity test
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维普
