The possible mechanism of Ershen Shaomai Decoction in the treatment of chronic atrophic gastritis(CAG)based on network pharmacology and molecular docking methods is explored.The active ingredients and CAG related targets of Ershen Shaomai Decoction are obtained through the database.The target of components of the Ershen Shaomai Decoction and disease targets are intermixed to obtain the target of Ershen Shaomai Decoction in treating CAG.A network diagram of"Chinese medicine-active ingredients-intersection-targets disease"is constructed and pathway enrichment analysis is performed.The research results show that Ershen Shaomai Decoction has the characteristics of multi-component,multi target,and multi pathway treatment for CAG.Through further target analysis,GO enrichment analysis,KEGG pathway enrichment analysis,protein interaction network,and molecular docking analysis,it is found that the main active ingredients of Ershen Shaomai Decoction,including luteolin,kaempferol,quercetin,β-sitosterol,stigmasterol,and isorhamnosum,may act on cancer pathways,NF-κB、JAK-STAT and other signaling pathways through AKT1、TP53、IL-6、TNF、BCL2、CASP3、IL-1B and other targets to treat CAG.
关键词
网络药理学/二参芍麦汤/分子对接/慢性萎缩性胃炎/作用机制
Key words
network pharmacology/Ershen Shaomai Decoction/molecular docking/chronic atrophic gastritis/mechanism of action
维普
万方数据