Objective To evaluate the clinical efficacy of full-endoscopic posterior lumbar interbody fusion(FE-PLIF)for the treatment of single-segment lumbar degenerative diseases.Methods From March 2019 to March 2021,27 patients with single-segment lumbar degenerative diseases were treated with FE-PLIF.The low back and leg pain visual analogue scale(VAS)scores and Oswestry disability index(ODI)were recorded at pre-operation and postoperative 3 d,3 months,6 months and 1 year.The occurrence of surgery-related complications and fusion rate at 1 year after surgery were recorded.Results All the operations were successfully completed.The VAS scores of low back and leg pain and ODI at each time point after surgery were significantly improved compared to pre-operation,and significantly improved at postoperative 3 months,6 months and 1 year compared to postoperative 3 d,all with a statistical significance(P<0.05).Postoperative hematoma occurred in 1 case,and no complications of nerve or vascular injury occurred in the remaining patients.At postoperative 1 year,25 patients had bone fusion,with a fusion rate of 92.6%(25/27).Conclusion FE-PLIF is safe and effective in the treatment of single-segment lumbar degenerative diseases,and the postoperative fusion rate is high.