Objective To compare the clinical efficacy and safety of percutaneous vertebroplasty(PVP)by noncoplanar bipedicular puncture method and coplanar bipedicular puncture method in the treatment of single-level mild osteoporotic vertebral compression fracture(OVCF).Methods From January 2019 to June 2022,75 patients with single-level mild OVCF were treated with PVP,including 40 cases(group A)by noncoplanar bipedicular puncture method and 35(group B)by coplanar bipedicular puncture method.The operation time,bone cement injection volume,leakage rate of bone cement,distribution grading of bone cement and incidence of complications were recorded and compared between the 2 groups.Pain severity was assessed by visual analogue scale(VAS)score at pre-operation and postoperative 1 d,3 months and 6 months.Lumbar function was assessed by Oswestry disability index(ODI).The clinical efficacy was evaluated by the modified MacNab criteria at the final follow-up.The anterior vertebral height and Cobb angle of the injured vertebra were measured on roentgenographs or CTs at pre-operation and at postoperative 1 d,3 months and 6 months.Results All the operations were successfully completed,and all the patients were followed up for more than 6 months.There was no significant difference in operation time between the 2 groups(P>0.05).The bone cement injection volume in group A was higher than that in group B;the leakage rate of bone cement was lower than that in group B;and the good rate of distribution grading of bone cement was higher than that in group B;the differences of the above indexes were statistically significant(P<0.05).The VAS score,ODI,anterior vertebral height and Cobb angle of injured vertebra were significantly improved at each follow-up time point of the 2 groups,all with a statistical significance(P<0.05);and there was no significant difference in the above indexes between the 2 groups at each follow-up time point(P>0.05).At the final follow-up,4 patients in group B experienced further collapse of injured vertebrae,and the other patients had no complications.The incidence of complications in group A was lower than that in group B,and the rate of excellent therapeutic effect was higher than that in group B,all with a statistical significance(P<0.05).Conclusion PVP by noncoplanar bipedicular puncture method and coplanar bipedicular puncture method in the treatment of single-level mild OVCF are effective,and the noncoplanar bipedicular puncture method has more advantages in bone cement leakage rate,bone cement distribution grading and complication rate.