Effect of Molybdenum Exposure on the Serum Biochemical Indexes of Male Mice
Objective To investigate the effect of molybdenum exposure on the serum biochemical indexes of male mice. Meth-ods A total of 50 male Kunming mice were selected and randomly divided into 5 groups based on their weight, with 10 mice in each group. Apart from control group ( physiological saline) , the other four groups were established according to the dosage of sodium mo-lybdate exposure, 3. 440 mg/kg group, 6. 880 mg/kg group, 34. 400 mg/kg group, and 68. 800 mg/kg group. All the mice had been exposed through daily intraperitoneal injection successively for 30 days. During the 30 days, their daily behavior and weight change were observed. After the exposure, the AST, ALT, LDH, Cr, BUN and UA in the serum samples collected from those cut-head mice were measured. Results With the increase of exposure dosage, the weight gain of these mice remained slow. The differ-ence in the weight gain between 34. 400 mg/kg and 68. 800 mg/kg groups and the control group was statistically significant (P<0. 05). The activity of ALT, AST and LDH in the serum enhanced with the increase of exposure dosage, and the difference between 68. 800 mg/kg group and the control group was statistically significant, so was the difference in the activity of ALT between 34. 400 mg/kg group and the control group. The content of Cr, BUN, and UA in all the groups rose. The difference in the rise between 34. 400 mg/kg and 68. 800 mg/kg groups and the control group was statistically significant. Conclusion High dosage of molybdenum exposure can inhibit the growth of male mice and influence the serum biochemical indexes of ALT, AST, LDH, Cr, BUN and UA, which suggests that molybdenum poisoning may bring damage of different degrees to the liver, heart and kidney.
NETL
NSTL
万方数据
维普
