Analysis of Risk Factors for Abnormal Liver Function in Breast Cancer Patients After Chemotherapy
Objective To screen the risk factors of abnormal liver function in breast cancer patients after chemotherapy.Meth-ods Medical records of 416 breast cancer chemotherapy patients admitted to 7 wards of Cancer Center of the First Affiliated Hospital of Jinzhou Medical University from July 2016 to November 2022 were retrospectively collected.General data,baseline blood routine,baseline biochemical indexes,and indicators of abnormal liver function after chemotherapy were recorded.The incidence,severity and time of abnormal liver function after chemotherapy were analyzed.The risk factors of abnormal liver function after chemotherapy were screened by Logistic regression analysis.Results Of the 416 patients,55.5%(281/416)had abnormal liver function,including 193(83.5%)in grade 1,28(12.1%)in grade 2,and 10(4.3%)in grade 3.The median time for first onset of abnormal liver function was 29 days,and the median cycle was the second cycle.Univariate Logistic analysis showed that abnormal liver function was correlated with age,hypertension,concomitant medication,BMI,abnormal fasting blood glucose,baseline liver function ALT,baseline liver function AST,baseline liver function TBil and baseline hemoglobin;multivariate Logistic regression analysis showed that BMI and baseline liver function ALT were independent risk factors for liver function abnormalities after chemotherapy(P<0.05).The cut-off value of BMI determined by ROC curve was 22.21,and the cut-off value of baseline liver function ALT was 17.5 U/L.Con-clusion BMI≥22.21 and baseline liver function ALT≥17.5 U/L may increase the risk of abnormal liver function after chemothera-py,and liver function should be closely monitored during chemotherapy in these patients.
breast cancerchemotherapyabnormal liver functionrisk factor
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