Predictive Value of sST2 and Gal-3 in Short-term Prognosis of Patients with Heart Failure
Objective To investigate the predictive value of combined detection of soluble Suppression of Tumorigenicity 2(sST2),Galectin-3(Gal-3)and NT-proBNP in patients with heart failure(HF).Methods A total of 144 patients with HF,including 84 males and 60 females,were selected from the First Affiliated Hospital of Jinzhou Medical University between February 2021 and October 2021.Clinical data were collected.Serum levels of sST2 and Gal-3 were measured by Elisa and NT-proBNP was measured by luminescence.The patients were followed up for 6 months after discharge,and the patients were divided into MACE group(n=40)and non-MACE group(n=104)according to the occurrence of Major Adverse Cardiovascular Events(MACE).The independent risk factors of MACE in patients with HF were analyzed by Logistic multivariate analysis.ROC curve was used to eval-uate the predictive value of combined detection of sST2,Gal-3 and NT-proBNP for short-term prognosis in patients with heart failure.Results The levels of NT-proBNP,sST2 and Gal-3 increased with the decrease of LVEF(P<0.05).Independent risk factors for MACE in patients with HF included LVEF(P=0.037,OR=0.901,95%CI=0.818～0.994)、NT-proBNP(P=0.032,OR= 2.087,95%CI=1.067～4.081)、sST2(P=0.030,OR=1.046,95%CI=1.004～1.089)、Gal-3(P=0.038,OR=1.062,95%CI=1.003～1.124).Correlation analysis showed that sST2 and Gal-3 were negatively correlated with LVEF(rs =-0.660,P<0.05;rs =-0.723,P<0.05)and positively correlated with NT-proBNP rs =0.586,P<0.05;rs =0.539,P<0.05),there was a positive correlation between sST2 and Gal-3(rs =0.668,P<0.05).sST2,Gal-3 have some predictive value for the prognosis of patients with HF.Combined detection of sST2,Gal-3 and NT-proBNP can improve the predictive value.Conclusion sST2 and Gal-3 are independent risk factors of MACE in patients with HF,and they are valuable in predicting the short-term prognosis of HF.Combined detection of sST2,Gal-3 and NT-proBNP can improve the predictive value.
heart failuresoluble suppression of tumorigenicity 2galectin-3N-terminal pro-B-type natriuretic peptideprognosis
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