Effects of OPN-305 Combined with Chemotherapy on Inflammation and Tumor Proliferation in a Mouse Model of Colitis-associated Cancer
Objective To study the effects of Toll-like receptor inhibitor OPN-305 combined with 5-fluorouracil and calcium fo-linate on inflammation and tumor proliferation in a mouse model of colorectal cancer associated with inflammatory bowel disease.Meth-ods 24 C57BL/6J wild-type mice were randomly divided into four groups,and all mice underwent CAC modeling.On days 0-44,the animal models of each group were given blank control in NC group with no special treatment,OPN-305 in OT group,5-FU+Lv in FT group,and OPN-35 combined with 5-FU+Lv in RT group.During this period,the clinical manifestations of mice were observed.After the modeling,the gross specimen measurement score of the colorectal of the animal model,the inflammation and oncology score of HE staining,and the influence of immunohistochemistry on tumor proliferation were evaluated.Results The clinical manifesta-tions,the degree of colon shortening,the number and volume of tumors,the inflammatory and oncology scores of histological stai-ning,and the proliferation of immunohistochemical tumors were significantly lower in RT group than those in NC group,OT group and FT group,and the differences were statistically significant.Conclusion OPN-305 combined with 5-F+Lv has inhibitory effects on inflammation and proliferation of tumor cells in CAC mouse models,and is superior to OPN-305 and 5-FU+Lv alone.
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