The Application of Systemic Immuno-inflammatory Index in the Assessment of Ulcerative Colitis
Objective To investigate the value of systemic immunoinflammatory index in evaluating the activity and lesion extent of ulcerative colitis.Methods A total of 103 UC patients admitted to Anshan Central Hospital from September 2021 to August 2023 and 80 healthy subjects during the same period were selected.The relevant clinical data and serological indicators of UC group and con-trol group were collected and analyzed,and the differences of these indicators between different activity degrees and lesion ranges were compared.The correlation between serological inflammatory markers and UC disease activity and lesion range was analyzed.Receiver operating characteristic curve was used to evaluate the diagnostic efficacy of each inflammatory index on UC activity and lesion extent.Results Compared with control group,SII in UC group was significantly increased(P＜0.05).Further analysis showed that there were statistically significant differences in SII levels among UC groups with different disease activity levels(P＜0.05);with the expan-sion of the lesion range in UC patients,the level of SII also increased(P＜0.05).Correlation analysis showed that SII level was posi-tively correlated with Mayo score and lesion range in UC patients(P＜0.05).ROC curve results showed that SII was better than other immunoinflammatory indicators in evaluating disease activity and lesion range in UC patients(AUC was 0.782 and 0.768,the best cutoff values were 512.143 and 677.99,and the sensitivity was 72.40％and 69.40％,respectively.The specificity was 81.30％and 76.10％,respectively).Conclusion The level of SII in UC patients is elevated and correlated with disease activity and lesion extent.In addition,SII has a higher predictive value for the activity and lesion extent of UC than other serological inflammatory indica-tors such as C-reactive protein(CRP)and Platelet-lymphocyte ratio(PLR).
ulcerative colitissystemic immune-inflammation indexdisease activityextent of lesion
万方数据
维普
