Analysis of the Detection Value of Peripheral Blood D-dimer and B-type Natriuretic Peptide in Patients with Acute Exacerbation of Interstitial Lung Disease
Objective To explore and analyze the detection value of peripheral blood D-dimer(D-D)and B-type natriuretic peptide(BNP)in patients with acute exacerbation of interstitial lung disease(ILD).Methods A total of 96 ILD patients admitted to Anyang People's Hospital from June 2021 to May 2023 were included in group A,while 45 healthy subjects were included in group B as control,and the differences in D-D and BNP levels between the two groups were compared;at the same time,all patients with acute ILD were followed up for 3 months after discharge,and were divided into death group and survival group according to whether the patients died or not.The general data,clinical characteristics and differences in D-D and BNP levels between the two groups were compared,and the predictive efficacy of D-D and BNP in the prognosis of patients with acute ILD were analyzed by ROC curve.Re-sults The levels of D-D and BNP in group A were significantly higher than those in group B(P＜0.05).After 3 months of follow-up,54 patients died,accounting for 56.25％,and 42 patients survived,accounting for 43.75％.The levels of D-D and BNP in death group were significantly higher than those in survival group(P＜0.05).There were no significant differences in gender,BMI and other general data between the death group and the survival group(P＞0.05).The death group was higher than the survival group in age,diabetes mellitus,dyspnea,hemoptysis,syncope and chest pain(P＜0.05).ROC curve analysis showed that the sensitivity of D-D,BNP and the combination in predicting the prognosis of acute ILD patients was 53.70％,70.37％and 83.33％,respective-ly.The specificity was 90.48％,78.57％,80.95％,respectively.AUC was 0.727,0.805 and 0.866,respectively(P＜0.05).Conclusion The levels of D-D and BNP were significantly changed in patients with acute ILD exacerbation,and D-D and BNP had high prognostic efficacy in patients with acute ILD exacerbation.
维普
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