Functional MRI Analysis of Repetitive Transcranial Magnetic Stimulation's Efficacy in Improving Cognitive Function in Vascular Dementia Patients
Objective To investigate the effect of repetitive transcranial magnetic stimulation(rTMS)on cognitive function in patients with vascular dementia(VD)by comparing the changes of brain activation volume in blood oxygen level dependent-functional magnetic resonance imaging(Bold-fMRI)before and after treatment;to explore the correlation between the increase of brain activa-tion volume and the improvement of cognitive function;to premilinary predicate and analyze the possible mechanism of rTMS.Meth-ods 38 VD patients admitted to the Outpatient and Inpatient Department of the First Affiliated Hospital of Jinzhou Medical University from January 2023 to October 2023 were divided into observation group(rTMS treatment group)and control group(routine treatment group)with 19 cases in each group.The scores of montreal cognitive assessment(MoCA)before and after treatment were compared between the two groups.According to the changes of brain activation volume in Bold-fMRI of the two groups,the correlation between cognitive function changes and brain activation volume increase was analyzed.Results After 2 months of rTMS treatment,the MoCA score of the observation group was significantly better than that of the control group(P<0.05).After rTMS treatment,the activation volume of bilateral dorsolateral prefrontal cortex(DLPFC)and bilateral ventrolateral prefrontal cortex(VLPFC)increased signifi-cantly in the observation group(P<0.05).After rTMS treatment,the activation volume of bilateral DLPFC and bilateral VLPFC in the observation group was positively correlated with MoCA score(P<0.01).Conclusion RTMS can effectively improve the cognitive function of VD patients and increase the activation volume of various brain regions in VD patients.The increase of activation volume of brain regions is related to the improvement of cognitive function,which may be related to the increase of blood flow in stimulating re-gions and their interacting brain regions.
vascular dementiacognitive functionrepetitive transcranial magnetic stimulationfunctional magnetic resonance imaging
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