Effect of Total Glucosides of Peony Capsules Combined with Leflunomide on Th1/Th2 Cell Balance and Peripheral Blood Monocyte Cells TLR4/NF-κB Signal Pathway in the Treatment of Rheumatoid Arthritis Patients
Objective To investigate the effect of total glucosides of paeony capsules combined with leflunomide on helper T cells(Th)1/Th2 cells balance and peripheral blood monocyte cells Toll-like receptor4(TLR4)/nuclear factor κB(NF-κB)signaling pathways in the treatment of rheumatoid arthritis(RA)patients.Methods 129 RA patients who were admitted to our hospital from April 2021 to December 2023 were divided into control group(n=64,treated with leflunomide tablets)and observation group(n=65,treated with total glucosides of paeony capsules combined with leflunomide tablets)according to the envelope drawing method.The efficacy,clinical symptoms,disease scores,disease related indicators,Th1/Th2 cells balance and peripheral blood TLR4/NF-κB signaling pathway related indicators between two groups were compared,and the occurrence of adverse reactions in two groups were observed.Results The total clinical effective rate in observation group was higher than that in control group(P<0.05).Compared with the control group,the morning stiffness time was shortened,the number of joint swelling and joint tenderness was reduced,the pain visual analogue scales(VAS)and the RA patients condition assessment(DAS28)scores were decreased,and C-reactive pro-tein,erythrocyte sedimentation rate,rheumatoid factor were decreased,Th2 cells were increased,Th1 cells,Th1/Th2 cells were decreased,TLR4 messenger RNA(mRNA),and NF-κB mRNA were decreased in observation group at 2 months after treatment(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Treatment of RA patients with total glucosides of paeony capsules combined with leflunomide,which can promote the improvement of patient symp-toms,and improve clinical treatment effectiveness,may be related to regulating Th1/Th2 cells balance and inhibition of TLR4/NF-κB signaling pathway activation in peripheral blood monocyte cells.
total glucosides of paeony capsulesleflunomiderheumatoid arthritisth1/th2tlr4/nf-κb signaling pathway
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