The Relationship Between Serum VEGF and ET-1 Expression and the Severity of Preeclampsia in Patients
Objective To analyze the relationship between the expression of serum vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)and the severity of preeclampsia in patients.Methods A prospective study was conducted,including 60 patients with preeclampsia who were diagnosed and treated in Fuyang Hospital of Anhui Medical University from January 2022 to January 2024 as the study subjects.All patients received routine intervention and regular prenatal checkups for preeclampsia.Patients who progressed to severe preeclampsia during regular prenatal checkups were included in the severe group,while patients who did not progress to other conditions were included in the mild group.The baseline data and serum VEGF and ET-1 expression at diagnosis were compared between the severe group and the mild group,and the relationship between serum VEGF and ET-1 expression and the severity of preeclampsia was analyzed.Results During regular prenatal examinations and interventions,8 out of 60 patients with preeclampsia experienced severe disease progression,accounting for 13.33％(8/60).There was no difference in baseline data such as age,body mass index(BMI)at diagnosis,maternal type,and gestational age between the severe and mild groups of patients(P＞0.05).When diagnosed,the blood pressure in the severe group was higher than that in the mild group,and the expression of serum VEGF and ET-1 was higher than that in the mild group,with statistical significant differences(P＜0.05).The development of mild preeclampsia to severe risk may be related to the serum VEGF and ET-1 levels at the time of diagnosis,and there was a positive dose-response relationship between the two(non-linear test P＜0.05).When serum VEGF＞6.48 pg/mL and ET-1＞48.24 ng/L were diagnosed in preeclampsia patients,the risk of developing to severe risk increased with the increase of serum VEGF and ET-1.The interaction found that the expression of serum VEGF and ET-1 in patients with preeclampsia had a positive interaction with the severity of the disease,that is,when the serum VEGF and ET-1 were highly expressed at the same time(VEGF＞5.80 pg/mL,ET-1＞47.26 ng/L),the risk of the patient's condition continuing to progress to severe was 8.889 times that of the serum VEGF and ET-1 at the same time(VEGF≤5.80 pg/mL,ET-1 ≤47.26 ng/L).Conclusion The severity of the condition in patients with preeclampsia may be related to the expression of serum VEGF and ET-1 at the time of diagnosis.As the expression of serum VEGF and ET-1 increases,the risk of disease progression in patients increases,and the impact of the two on the severity of the condition is interactive.
preeclampsiadegree of illnessserum vascular endothelial growth factorserum endothelin-1
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