摘要
小檗碱具有广泛的药理活性,除抗炎、抗感染、降血糖、调血脂、心脏保护等作用外,对胃癌、乳腺癌、膀胱癌、肝癌等还具有显著的抗肿瘤作用,是一个潜在的抗肿瘤药物.该文主要围绕小檗碱对甲状腺癌、鼻咽癌、口腔鳞癌、舌癌、喉癌、腺样囊性癌等头颈部肿瘤和脑癌的药理作用及其机制进行了综述和分析,为小檗碱的后续开发提供理论支撑.
Abstract
Berberine has a wide range of pharmacological activities.In addition to anti-inflammatory,anti-infectious,hypoglycemic,blood-lipid regulating and cardioprotective functions,it has significant anti-tumor effects on gastric cancer,breast cancer,bladder cancer,liver cancer,etc.It is a potential anti-tumor drug.In this article,the pharmacological effects of berberine against head-neck tumors such as thyroid cancer,nasopharyngeal cancer,oral squamous cell carcinoma,tongue cancer,laryngeal cancer and adenoid cystic carcinoma,and brain cancer and the related mechanisms of action are reviewed and analyzed,to provide theoretical support for the subsequent development of berberine.
维普
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