皮肤试验预测头孢菌素过敏反应的研究进展
Research Progress in Predicting Anaphylactic Response of Cephalosporins by Skin Test
罗俊 1刘国萍 1黄舒文 1覃福礼 1韦坤璇1
作者信息
- 1. 广西医科大学第一附属医院药学部,南 宁 530021
- 折叠
摘要
头孢菌素是以 7-氨基头孢烷酸(7-amino-cephalosporanic acid)为母核,通过连接不同侧链而形成的一类β-内酰胺类抗菌药物.通过不断迭代研发,头孢菌素在抗菌谱、抗菌作用和药物安全性等方面得到不断优化.然而,在临床使用过程中,头孢菌素仍会出现过敏反应等药物不良反应,国内一直以来都是通过皮肤试验进行预测,但相关研究对皮肤试验的预测和应用价值是存在质疑的.为此,笔者从β-内酰胺类药物致过敏反应的分子机制和影响因素、皮肤试验的经济学价值、国内外头孢菌素的皮肤试验开展现状等方面对相关研究进行了综述,为临床评估皮肤试验对头孢菌素过敏反应的预测价值和应用前景提供参考.
Abstract
Cephalosporins are a class of β-lactam antibacterial drugs formed by linking different side chains with 7-amino-cephalosporanic acid as the mother nucleus.Through continuous iterative research and development,cephalosporins have been continuously optimized in terms of antibacterial spectrum,antibacterial effect and drug safety,etc.However,cephalosporins may induce anaphylactic response and other adverse drug reactions(ADRs)in clinical use.For a long time,ADRs are predicted by skin test in China,but relevant studies have questioned the predictive and application value of skin tests.For this purpose,the relevant studies have been reviewed in terms of the molecular mechanisms and influencing factors of anaphylactic responses caused by β-lactam drugs,the economic value of skin tests,and the current status of skin tests of cephalosporins carried out at home and abroad,etc.,so as to provide reference for clinical assessment of the predictive value and application prospects of skin tests for anaphylactic responses of cephalosporins.
关键词
皮肤试验/头孢菌素/过敏反应/研究进展Key words
skin test/cephalosporins/anaphylactic response/research progress引用本文复制引用
基金项目
广西卫生健康委自筹经费科研课题(Z20201369)
广西药学会医院药学科研项目(GXYXH1-202203)
出版年
2024
NETL
NSTL
万方数据