Research Progress in Predicting Anaphylactic Response of Cephalosporins by Skin Test
Cephalosporins are a class of β-lactam antibacterial drugs formed by linking different side chains with 7-amino-cephalosporanic acid as the mother nucleus.Through continuous iterative research and development,cephalosporins have been continuously optimized in terms of antibacterial spectrum,antibacterial effect and drug safety,etc.However,cephalosporins may induce anaphylactic response and other adverse drug reactions(ADRs)in clinical use.For a long time,ADRs are predicted by skin test in China,but relevant studies have questioned the predictive and application value of skin tests.For this purpose,the relevant studies have been reviewed in terms of the molecular mechanisms and influencing factors of anaphylactic responses caused by β-lactam drugs,the economic value of skin tests,and the current status of skin tests of cephalosporins carried out at home and abroad,etc.,so as to provide reference for clinical assessment of the predictive value and application prospects of skin tests for anaphylactic responses of cephalosporins.
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