Research Progress in Pharmacological Effect and Mechanism of Berberine against Colorectal Cancer
Colorectal cancer is a malignant tumor with high incidence and mortality in China.Berberine is a quaternary ammonium alkaloid with a wide range of biological activities.In addition to anti-inflammatory,anti-infective,hypoglycemic,blood-lipid regulating and cardioprotective functions,it can inhibit the formation of tumor cells,induce apoptosis,suppress proliferation and affect diffusion,etc.In this article,the preventive effect of berberine on colorectal cancer and its inhibitory effects on colorectal cancer cells HT29,HCT116,SW480,SW620,CT26,etc.,as well as related mechanisms are reviewed and analyzed,to provide reference for the clinical development of berberine in the future.
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