摘要
结直肠癌是我国发病率和病死率均较高的恶性肿瘤.小檗碱为季铵生物碱,具有广泛的生物活性,除抗炎、抗感染、降血糖、调血脂、心脏保护等作用外,还能抑制肿瘤细胞的形成、诱导凋亡、抑制增殖、影响扩散等.该文从小檗碱对结直肠癌的预防作用,以及对结直肠癌细胞HT29、HCT116、SW480、SW620、CT26等的抑制作用及其机制等方面进行了综述和分析,为小檗碱后期的临床开发提供参考.
Abstract
Colorectal cancer is a malignant tumor with high incidence and mortality in China.Berberine is a quaternary ammonium alkaloid with a wide range of biological activities.In addition to anti-inflammatory,anti-infective,hypoglycemic,blood-lipid regulating and cardioprotective functions,it can inhibit the formation of tumor cells,induce apoptosis,suppress proliferation and affect diffusion,etc.In this article,the preventive effect of berberine on colorectal cancer and its inhibitory effects on colorectal cancer cells HT29,HCT116,SW480,SW620,CT26,etc.,as well as related mechanisms are reviewed and analyzed,to provide reference for the clinical development of berberine in the future.
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