中药致肝损伤的研究进展
Research Progress in TCM-induced Liver Injury
石子叶 1张妍 2徐旭 3林娟 4徐科一 4李楚源 4李鹏4
作者信息
- 1. 天津中医药大学研究生院,天津 301617
- 2. 天津药物研究院药业有限责任公司,天津 300301
- 3. 天津药物研究院(天津市中药质量标志物重点实验室),天津 300301;天津药物研究院(药物成药性评价与系统转化全国重点实验室),天津 300301
- 4. 广州白云山和记黄埔中药有限公司,广州 510515
- 折叠
摘要
中药因其确切的疗效和较好的安全性,数千年来一直守护着华夏人民的健康.但部分中药受其自身特性、炮制工艺、配伍组方等影响,可能对肝脏造成较大负担,甚至具有毒性,从而导致肝损伤.该文对引发肝损伤的常见中药及其发生机制做了综述,并从炮制、配伍、剂型改造和给药方式等方面探讨了针对中药肝毒性的减毒措施,为中药的用药安全提供参考.
Abstract
Traditional Chinese medicines(TCMs)have been protecting the health of the Chinese people for thousands of years due to their exact efficacy and good safety.However,some TCMs may cause a great burden on the liver and may even have toxicity because of their own characteristics,processing techniques,and compatibility of prescription,leading to liver injury.In this article,common TCMs that induce liver injury and their mechanisms are reviewed,and the measures for reducing hepatotoxicity of TCMs are discussed in terms of processing,compatibility,dosage form modification,and methods of administration,etc.,to provide reference for the medication safety of TCMs.
关键词
中药/肝损伤/作用机制/减毒措施Key words
traditional Chinese medicines/liver injury,mechanism of action/measures for reducing hepatotoxicity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据