首页|某院上报的药物不良反应的流行病学分析

某院上报的药物不良反应的流行病学分析

扫码查看
目的:分析医院上报的药物不良反应(adverse drug reactions,ADRs)的发生特点和规律,为临床安全合理用药提供参考。方法:选取 2022 年 7 月—2023 年 6 月濮阳市安阳地区医院上报至国家药品不良反应监测系统的 311 例ADRs报告作为研究资料,采集ADRs的报告类型和累及器官、所涉患者的年龄和性别、所涉药物品种和剂型等信息,分析医院内ADRs的发生特点和规律。结果:311 例ADRs报告中,报告类型主要为"一般的"(271 例,占 87。14%),"严重的"(22 例,占 7。07%)和"新的一般的"(16 例,占 5。14%)较少;在性别上,女性略多于男性(164 例vs 147 例);在年龄上,ADRs主要发生于>40 岁者(260 例,占 83。60%);在药物方面,311 例ADRs涉及 12 类 107 种药品,其中主要的类为中枢神经系统用药(60 例,占 19。29%)、心血管系统用药(53 例,占 17。04%)、抗感染药物(50 例,占 16。08%);而涉及的药品剂型主要为注射液(194 例,占 62。38%),其次为粉针剂(88 例,占28。30%);在累及器官方面,311 例ADRs 主要累及胃肠道系统(76 例,占 24。44%)、皮肤及其附件(56 例,占18。01%)和神经系统(53 例,占 17。04%)。结论:医院所上报的ADRs主要发生于 40 岁以上的中老年,并且所用药物多为注射剂,尽管其中新的或严重的ADRs发生较少,但临床仍应当做好用药后的监测,以确保患者的用药安全。
Epidemiological Analysis of Adverse Drug Reactions Reported by a Hospital
Objective:To analyze the occurrence characteristics and patterns of adverse drug reactions(ADRs)reported by a hospital and provide reference for safe and rational medications in the clinics.Methods:A total of 311 ADR reports reported by Puyang Anyang District Hospital to the National Adverse Drug Reaction Monitoring System from July 2022 to June 2023 were used as research data,and the information such as the types and involved organs of ADR reports,the age and gender of involved patients and the types and dosage forms of involved drugs,etc.was collected,to analyze the occurrence characteristics and patterns of ADRs in the hospital.Results:Among the 311 ADR reports,the report types were mainly"ordinary"(271 cases,87.14%),while the types of"serious"(22 cases,7.07%)and"new and ordinary"(16 cases,5.14%)were less;in terms of gender,females were slightly more than males(164 cases vs 147 cases);in terms of age,ADRs mainly occurred in people aged above 40 years(260 cases,83.60%);in terms of drugs,311 ADRs involved 107 types of drugs in 12 categories,mainly drugs for central nervous system(60 cases,19.29%),cardiovascular system(53 cases,17.04%),and anti-infective drugs(50 cases,16.08%);the dosage forms of drugs were mainly injections(194 cases,62.38%),followed by powder injections(88 cases,28.30%);in terms of organs involved,311 ADRs mainly involved the gastrointestinal system(76 cases,24.44%),skin and its appendages(56 cases,18.01%)and nervous system(53 cases,17.04%).Conclusion:ADRs reported by the hospital mainly occur in middle-aged and elderly people aged above 40 years,and the drugs used are mostly injections.Although new or serious ADRs occur less frequently,clinical monitoring after medications should still be performed to ensure the medication safety of patients.

adverse drug reactionsepidemiological characteristicsrational drug use

胡小倩

展开 >

濮阳市安阳地区医院,河南 安阳 455000

药物不良反应 流行病学特点 合理用药

河南省医学科技攻关计划

LHGJ20220979

2024

抗感染药学
江苏省苏州市第五人民医院

抗感染药学

影响因子:0.505
ISSN:1672-7878
年,卷(期):2024.21(3)
  • 11