Research on the Correlation between the Use of Antibacterial Drugs and Imipenem-resistant Acinetobacter Baumannii in Tertiary Teaching Hospitals in Xuzhou and Nanjing
Objective:To analyze the correlation between the use of antibacterial drugs and imipenem-resistant Acinetobacter Baumannii in tertiary teaching hospitals in Xuzhou and Nanjing,Jiangsu Province,and to provide reference for clinical reduction of imipenem-resistant Acinetobacter baumannii(IRAB).Methods:A total of 15434 strains of Acinetobacter baumannii detected from inpatient specimen from two tertiary teaching hospitals in Xuzhou and four tertiary teaching hospitals in Nanjing from January 2019 to December 2021 were used as the research objects,and the correlation between the use of antibacterial drugs and IRAB in hospitals of Nanjing and Xuzhou in three years was analyzed using the correlation coefficient method and linear regression method.Results:From 2019 to 2021,the composition ratio of IRAB in Xuzhou and Nanjing showed a significant increase trend,while the use of carbapenems,β-lactams and fluoroquinolones was significantly related to the composition ratio of IRAB(P<0.05).Conclusion:Reducing the use of carbapenems,piperacillin tazobactam sodium,fluoroquinolones and other antibacterial drugs may help to reduce IRAB.
use of antibacterial drugsimipenem-resistant Acinetobacter baumanniicorrelation
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