Pharmaceutical Analysis of Anti-infection Treatment in a Patient with Pulmonary Cryptococcosis
Objective:To analyze the diagnosis and treatment process of a patient with cryptococcal infection,and to provide reference for the treatment of patients suffering from cryptococcosis.Methods and Results:The patient was admitted to the department of respiratory and critical care medicine of the hospital for treatment due to"pneumonia",and was given expectorant and anti-infection treatment in the emergency;on Day 5 after admission,pulmonary cryptococcosis was diagnosed according to serum cryptococcal capsule antigen examination,lung CT imaging results and inflammatory index results of the patient,and then the anti-infection treatment with fluconazole sodium chloride injection was added.Through analysis of anti-infection treatment of patients with pulmonary cryptococcosis,and in combination with the clinical symptoms,medication adjustment and patient outcomes and reference to relevant literature,the clinical pharmacist considered that the patient was obese with a body mass index of 28.In order to ensure the effective blood concentration in the body,the loaded dose of fluconazole could be 0.84 g,and intravenous drip of the fluconazole sodium chloride injection(400 mg,q12h)was recommended;on Day 7 after admission,the clinical symptoms of the patient improved,and the frequency of the fluconazole sodium chloride injection for anti-infection treatment was reduced(0.4 g,q24 h);on Day 13 after admission,the lung CT of the patient showed that the inflammation had progressed,and anti-infection treatment was continued.On Day 17 after admission,the patient's general condition was good and the patient was approved to discharge from the hospital.Conclusion:In the process of cryptococcal anti-infection treatment,clinical pharmacists actively carry out pharmaceutical care and medication education,in combination with the actual situation of the patient,fully consider the influence of basic diseases(diabetes)on infection and self-resistance and the physical condition of the patient,take into account adverse drug reactions and interactions,and formulate individualized medication regimens,thus obtaining valuable experience in formulating treatment regimens for pulmonary cryptococcosis.
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