基于文献与实例的莫西沙星所致严重过敏反应的流行病学分析

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中文摘要：目的:基于文献与相关实例，分析莫西沙星所致严重过敏反应的流行病学特征，为临床莫西沙星的用药安全提供参考。方法:以"莫西沙星(moxifloxacin)"、"超敏反应(hypersensitivity)"、"过敏反应(anaphylaxis)"等为关键词，在中国知网、重庆维普、万方数据库、PubMed、Embase等国内外数据库中检索莫西沙星所致严重过敏反应的相关文献，采集患者的相关流行病学信息，结合医院此前上报的 1 例莫西沙星所致严重过敏反应的药物不良反应报告，分析莫西沙星所致严重过敏反应的临床特点。结果:在国内外数据库中共检索到莫西沙星所致严重过敏反应的相关文献 13 篇，涉及患者 15 例;在总共 16 例患者中，女性明显多于男性(15 例vs 1 例)，＜60 岁者14 例，≥60 岁者 4 例;潜伏期≤1h者 9 例，潜伏期＞1 h～7 d者 6 例;发生超敏反应综合征的有 3 例，而超敏反应的有 10 例;在转归方面，11 例患者在停药并给予糖皮质激素或抗组胺类药物后好转，4 例患者在停用但未予以药物治疗的情况下也好转，有 1 例患者因发生爆发性肝衰竭而最终死亡。结论:莫西沙星所致过敏反应多发生于女性患者，且潜伏期较短，其严重程度可从较轻的皮疹、瘙痒到较重的呼吸困难，甚至死亡，故临床在应对莫西沙星所致药物不良反应时，应做到早识别、早处置，以确保患者的用药安全。

外文标题：Epidemiological Analysis of Severe Allergic Reactions Caused by Moxifloxacin Based on Literatures and Examples

外文摘要：Objective:To analyze the epidemiological characteristics of severe allergic reactions caused by moxifloxacin based on literatures and relevant examples,and provide a reference for clinically safe use of moxifloxacin.Methods:By using"moxifloxacin",'hypersensitivity","anaphylaxis",etc.as keywords,relevant literature on severe allergic reactions caused by moxifloxacin was searched in Chinese and foreign databases such as CNKI,Chongqing VIP,Wanfang Database,PubMed,and Embase,and relevant epidemiological information of patients was collected.Combined with the adverse drug reaction report of one patient with severe allergic reaction caused by moxifloxacin previously reported by the hospital,the clinical characteristics of severe allergic reactions caused by moxifloxacin were analyzed.Results:A total of 13 articles on severe allergic reactions caused by moxifloxacin were searched from Chinese and foreign databases,involving 15 patients.Among the 16 patients in total,there were significantly more females than males(15 vs 1);there were 14 patients aged less than 60 years and 4 patients aged not less than 60 years;9 patients with a latency period of not more than 1 hour and 6 patients with a latency period of more than 1 hour and less than 7 days;3 patients who developed hypersensitivity syndrome and 10 patients who had hypersensitivity.In terms of outcomes,11 patients improved after drug discontinuation and administration of glucocorticoids or antihistamines,4 patients improved after drug discontinuation but without medication,and 1 patient eventually died of fulminant hepatic failure.Conclusion:Allergic reactions caused by moxifloxacin mostly occur in female patients,and the latency period is short.The severity includes mild rash and itching,severe dyspnea and even death.Therefore,when handling adverse drug reactions caused by moxifloxacin,it is necessary to implement early identification and early management to ensure medication safety of patients.

外文关键词：

moxifloxacinallergic reactionhypersensitivityadverse drug reactionsepidemiological characteristics

作者：

金芬、王萌萌、卜学彬、黄晨

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作者单位：

武汉市第七医院药剂科,武汉 430071

关键词：

莫西沙星过敏反应超敏反应药物不良反应流行病学特点

出版年：

2024

DOI：