某院老年患者抗菌药物所致药物不良反应的临床特征分析

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中文摘要：目的:分析医院老年患者抗菌药物所致药物不良反应(adverse drug reactions，ADRs)的临床特点，为临床老年患者抗菌药物的用药安全提供参考。方法:选取 2018 年 1 月—2022 年 6 月新余钢铁集团有限公司中心医院上报的 80 例抗菌药物所致ADRs老年病例作为研究对象，采集相关抗菌药物的品种和给药途径，以及ADRs的临床表现和严重程度，分析老年患者发生抗菌药物相关ADRs的临床特点。结果:80 例ADRs涉及的抗菌药物主要为喹诺酮类(33 例，占 41。25%)和β-内酰胺类/β-内酰胺酶抑制剂复合制剂(27 例，占 33。75%)，涉及的具体品种主要由头孢哌酮-舒巴坦钠、哌拉西林-他唑巴坦钠、左氧氟沙星和莫西沙星;80 例ADRs所涉抗菌药物的给药途径主要为静脉滴注(70 例，占 87。50%);80 例ADRs 累及的主要器官(或系统)主要为皮肤及其附件(32 例，占40。00%)、中枢和外周神经系统(20 例，占 25。00%)、胃肠道系统(16 例，占 20。00%);80 例ADRs中，有 10 例为严重ADRs，其余均为一般ADRs。结论:喹诺酮类和β-内酰胺类/β-内酰胺酶抑制剂复合制剂在老年患者抗菌药物所致ADRs中占比较高，尤其是其静脉滴注剂型;对此，临床应加强老年患者抗菌药物的用药管理和监护，以保证患者的用药安全。

外文标题：Analysis of Clinical Characteristics of Adverse Drug Reactions Caused by Antibacterial Drugs in Elderly Patients in a Hospital

外文摘要：Objective:To analyze the clinical characteristics of adverse drug reactions(ADRs)caused by antibacterial drugs in elderly patients in the hospital,and provide a reference for the clinically safe use of antibacterial drugs in elderly patients.Methods:A total of 80 elderly patients with ADRs caused by antibacterial drugs reported by XinSteel Central Hospital from January 2018 to June 2022 were used as the research objects.The information on the types and routes of administration of related antibacterial drugs,and the clinical manifestations and severity of ADRs was collected to analyze the clinical characteristics of ADRs related to antibacterial drugs in elderly patients.Results:The main antibacterial drugs involved in the 80 cases of ADRs were quinolones(33 cases,41.25%)and β-lactam/β-lactamase inhibitor compound preparations(27 cases,33.75%).The specific varieties involved were mainly cefoperazone-sulbactam sodium,piperacillin-tazobactam sodium,levofloxacin and moxifloxacin.The route of administration of the antibacterial drugs involved in the 80 cases of ADRs was mainly intravenous drip(70 cases,87.50%).The main organs(or systems)involved in the 80 cases of ADRs were skin and appendages of skin(32 cases,40.00%),central and peripheral nervous systems(20 cases,25.00%),and gastrointestinal system(16 cases,20.00%).Among the 80 cases of ADRs,10 were severe ADRs,and the others were general ADRs.Conclusion:The proportion of quinolones and β-lactam/β-lactamase inhibitor compound preparations is high among the antibacterial drugs causing ADRs in elderly patients,especially their intravenous drip formulations.Therefore,it is necessary to clinically strengthen the medication management and monitoring of antibacterial drugs in elderly patients to ensure the safe medication of patients.

外文关键词：

elderly patientsantibacterial drugsadverse drug reactionsclinical characteristics

作者：

吴忧、胡海生、白倩、葛星峰

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作者单位：

新余钢铁集团有限公司中心医院,江西新余 338000

关键词：

老年患者抗菌药物药物不良反应临床特征

出版年：

2024

DOI：