Research Progress in the Treatment of Septic Shock with Levosimendan
Septic shock occurs when pathogenic microorganisms and their toxins invading the blood circulation activate the host's cellular and humoral immune systems,producing various cytokines and inflammatory mediators to cause systemic inflammatory response syndrome,and further act on various organs and systems,causing histiocytic destruction,metabolic disorders,dysfunction,and even multiple organ dysfunction,ultimately leading to a critical syndrome with shock as a prominent manifestation.Levosimendan,as a calcium ion sensitizer,can not only improve myocardial contractility without increasing cellular oxygen consumption,but also dilate coronary arteries and systemic blood vessels,thereby improving hemodynamics.In this article,the epidemiological characteristics and pathogenesis of septic shock,the pharmacological effects and mechanisms of levosimendan,and the application and potential risks of levosimendan in septic shock are mainly reviewed,to provide a reference for the clinical use of levosimendan.
万方数据
维普
