抗感染药学2024，Vol.21Issue(7) ：691-694.DOI:10.13493/j.issn.1672-7878.2024.07-006

某院抗结核药物所致药物不良反应的流行病学特征分析

Analysis of Epidemiological Characteristics of Adverse Drug Reactions Caused by Anti-tuberculosis Drugs in a Hospital

涂上卿 张鎏 张嵩 汤博文 傅品祥
抗感染药学2024，Vol.21Issue(7) ：691-694.DOI:10.13493/j.issn.1672-7878.2024.07-006
✕
  • 维普
  • 万方数据

某院抗结核药物所致药物不良反应的流行病学特征分析

Analysis of Epidemiological Characteristics of Adverse Drug Reactions Caused by Anti-tuberculosis Drugs in a Hospital

涂上卿 1张鎏 2张嵩 1汤博文 2傅品祥2
扫码查看

作者信息

  • 1. 上饶市人民医院感染性疾病科,江西 上饶 334000
  • 2. 上饶市第二人民医院呼吸与危重症医学科,江西 上饶 334000
  • 折叠

摘要

目的:分析医院抗结核药物所致药物不良反应(adverse drug reactions,ADRs)的流行病学特征,为临床抗结核药物的用药安全提供参考.方法:选取 2020 年 1 月—2023 年 12 月医院收治的 897 例进行抗结核治疗的结核病患者作为研究对象,统计患者抗结核药物所致ADRs的发生情况,并采集患者的年龄,以及ADRs的发生时间、临床表现、严重程度等信息,以分析抗结核药物所致ADRs的临床特点.结果:897 例结核病患者中发生抗结核药物相关ADRs的有 378 例,ADRs发生率为 42.14%;378 例ADRs患者的年龄主要集中在＞60 岁(192 例,占50.79%),其次为＞40～60 岁(90 例,占 23.81%)和＞18～40 岁(81 例,占 21.43%);抗结核药物所致ADRs的发生时间以用药后的＞15～30 d居多(123 例,占 32.54%),其次为用药后的≤15 d(78 例,占 20.63%)和＞45～60 d(76 例,占 20.11%);抗结核药物所致的ADRs主要表现为肝功能损伤(141 例,占 37.30%)、胃肠道反应(90 例,占 23.81%)和泌尿系统异常(69 例,占 18.25%);抗结核药物所致ADRs的严重程度以轻度为主(287 例,占 75.93%),重度的仅 6 例(占 1.59%).结论:医院抗结核药物相关ADRs的发生率较高,其发生人群以中老年为主,其症状表现多较为轻微,对此临床仍应高度重视,做好患者的用药监测,以保障患者的用药安全.

Abstract

Objective:To analyze the epidemiological characteristics of adverse drug reactions(ADRs)caused by anti-tuberculosis drugs in the hospital and provide a reference for the safe medication of anti-tuberculosis drugs in clinical practice.Methods:A total of 897 patients with tuberculosis admitted to the hospital for anti-tuberculosis treatment from January 2020 to December 2023 were selected as research objects,the occurrence of ADRs caused by anti-tuberculosis drugs was summarized,and the information of patients such as age,occurrence time,clinical manifestations and severity of ADRs was collected to analyze the clinical characteristics of ADRs caused by anti-tuberculosis drugs.Results:Among 897 tuberculosis patients,anti-tuberculosis drug-related ADRs occurred in 378 patients,with an ADR incidence of 42.14%,and the ages of the 378 patients with ADRs were mainly elder than 60 years old(192 cases,50.79%),followed by 40-60 years old(90 cases,23.81%)and 18-40 years old(81 cases,21.43%).The ADRs caused by anti-tuberculosis drugs mostly occurred in 15-30 days after medication(123 cases,32.54%),followed by less than and equal to 15 days after medication(78 cases,20.63%),and 45-60 days after medication(76 cases,20.11%).ADRs caused by anti-tuberculosis drugs were mainly manifested as liver damage(141 cases,37.30%),gastrointestinal reactions(90 cases,23.81%)and urinary system abnormalities(69 cases,18.25%).For the severity of ADRs caused by anti-tuberculosis drugs,most of them were mild(287 cases,75.93%)and only 6 cases(1.59%)were severe.Conclusion:The anti-tuberculosis drug-related ADRs have a high incidence in hospitals,and the target populations are mainly middle-aged and elderly people,and their symptoms are mostly mild.Clinically,it is necessary to attach importance to them,monitor their medications to ensure the safe medication of patients.

关键词

结核病/抗结核药物/药物不良反应/临床特征

Key words

tuberculosis/anti-tuberculosis drugs/adverse drug reactions/clinical characteristics

引用本文复制引用

出版年

2024
抗感染药学
江苏省苏州市第五人民医院

抗感染药学

影响因子：0.505
ISSN：1672-7878
段落导航相关论文