Research Progress in Novel β-Lactam/β-Lactamase Inhibitor Compound Preparation Cefepime-Taniborbactam Sodium
Bacterial resistance is a global public health problem,especially carbapenem-resistant Gram-negative bacteria(CR-GNB)have more serious harm.Clinically,there are very limited methods for prevention and treatment of CR-GNB infection,so novel antibacterial drugs are urgently needed.Cefepime-taniborbactam sodium is a compound preparation composed of the fourth-generation cephalosporin cefepime and the novel broad-spectrum β-lactamase inhibitor taniborbactam sodium,and has direct inhibitory activity against four types of β-lactamases(types A,B,C and D),so it may have good antibacterial effects on CR-GNB and other drug-resistance bacteria.In this article,the mechanism of action,pharmaceutical properties,antibacterial activity,clinical study,enzyme inhibition/antibacterial spectrum of cefepime and taniborbactam sodium are reviewed,so as to provide reference for the rational clinical use of cefepime-taniborbactam sodium.
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