Objective:To analyze the clinical characteristics of polymyxin B-induced neuromuscular block based on actual cases and relevant literature reports,and provide reference for the clinical medication safety of polymyxin B.Methods:The clinical characteristics for occurrence of one patient with polymyxin B-induced neuromuscular block were collected,and the relevant literatures were searched from Chinese and foreign databases using"polymyxin","neurotoxicity"or"neuromuscular block"as keywords.The relevant data of the reported cases were collected,and the clinical characteristics of polymyxin B-induced neuromuscular block were analyzed.Results:A total of 6 valid articles were searched,involving 8 cases.Among 9 cases with polymyxin B-induced neuromuscular block,8 cases occurred within 5 days after the first medication,with the main clinical manifestations of dyspnea(7 cases)and perioral abnormality(5 cases).Six patients with dyspnea underwent endotracheal intubation or tracheotomy.After treatment,one case died of septic shock,and the rest cases improved or were cured.Conclusion:Neuromuscular block is a rare adverse reaction of polymyxin B.Although rare,its consequences are serious,especially special attention should be paid to dyspnea.Therefore,clinical monitoring of the use of polymyxin B should be strengthened to ensure the safe medication for patients.
关键词
多黏菌素B/神经肌肉阻滞/呼吸困难/药物不良反应
Key words
polymyxin B/neuromuscular block/dyspnea/adverse drug reactions
维普
万方数据