Case Analysis and Literature Review of Polymyxin B-Induced Neuromuscular Block
Objective:To analyze the clinical characteristics of polymyxin B-induced neuromuscular block based on actual cases and relevant literature reports,and provide reference for the clinical medication safety of polymyxin B.Methods:The clinical characteristics for occurrence of one patient with polymyxin B-induced neuromuscular block were collected,and the relevant literatures were searched from Chinese and foreign databases using"polymyxin","neurotoxicity"or"neuromuscular block"as keywords.The relevant data of the reported cases were collected,and the clinical characteristics of polymyxin B-induced neuromuscular block were analyzed.Results:A total of 6 valid articles were searched,involving 8 cases.Among 9 cases with polymyxin B-induced neuromuscular block,8 cases occurred within 5 days after the first medication,with the main clinical manifestations of dyspnea(7 cases)and perioral abnormality(5 cases).Six patients with dyspnea underwent endotracheal intubation or tracheotomy.After treatment,one case died of septic shock,and the rest cases improved or were cured.Conclusion:Neuromuscular block is a rare adverse reaction of polymyxin B.Although rare,its consequences are serious,especially special attention should be paid to dyspnea.Therefore,clinical monitoring of the use of polymyxin B should be strengthened to ensure the safe medication for patients.
polymyxin Bneuromuscular blockdyspneaadverse drug reactions
万方数据
维普
