首页|某三甲综合医院2020-2022年所上报药物不良反应的临床特征分析

某三甲综合医院2020-2022年所上报药物不良反应的临床特征分析

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目的:分析医院 2020-2022 年所上报药物不良反应(adverse drug reactions，ADRs)的临床特点，为临床患者的用药安全提供参考。方法:选取 2020 年 1 月—2022 年 12 月苏州大学附属第一医院上报至国家药品不良反应监测中心的 1 971 例ADRs报告作为研究资料，采集其中患者的年龄、ADRs的临床表现和累及器官，以及ADRs所涉药物的种类、剂型、给药方式等信息，分析ADRs的临床特点。结果:1 971 例ADRs报告中，患者的年龄主要集中于≥40 岁(1 643 例，占 83。36%);3 年间，ADRs所涉药物的剂型均以注射液为最多，其次为片剂，随之给药途径主要为静脉滴注，其次为口服;3 年间，前 10 位ADRs所涉药品均主要为碘克沙醇注射液、华法林钠片和抗肿瘤药物，并且抗肿瘤药物ADRs的报告数呈逐年上升趋势;1 971 例ADRs报告的报告类型主要为"一般"(1 442 例，占 73。16%)，但"严重"的也有 529 例(占 26。84%);529 例严重ADRs主要累及的免疫系统(136 例，占25。71%)、消化系统(113 例，占 21。36%)、皮肤及其附件(93 例，占 18。58%)和循环系统(93 例，占 18。58%);而严重ADRs的影响主要为"导致患者住院或住院时间延长"(268 例，占 50。66%)和"导致其他重要医学事件"(223 例，占42。16%)，但也有 35 例(占 6。62%)危及了患者的生命。结论:中老年是ADRs的高发人群，并且严重ADRs的发生比例较高，对此临床应持续加强患者的用药宣教和监测，以保证患者能在发生ADRs的第一时间得到救治，进而保障患者的用药安全。
Analysis of Clinical Characteristics of Adverse Drug Reactions Reported in a Three-A General Hospital from 2020 to 2022
Objective:To analyze the clinical characteristics of adverse drug reactions(ADRs)reported in the hospital from 2020 to 2022,and provide reference for the clinical safe medication for patients.Methods:The ADR reports of 1 971 cases reported to China National Center for ADR Monitoring by the First Affiliated Hospital of Soochow University from January 2020 to December 2022 were selected as research data.The information such as patient age,clinical manifestations of ADRs and involved organs,as well as types,dosage forms,and administration methods of drugs involved in ADRs was collected to analyze the clinical characteristics of ADRs.Results:In the ADR reports of 1 971 cases,the age of patients was mainly 40 years old or above(1 643 cases,83.36%).In the three years,the dosage form of drugs involved in ADRs was mainly injection,followed by tablets;the main route of administration was intravenous drip,followed by oral administration;the top 10 drugs involved in ADRs were mainly iodixanol injections,warfarin sodium tablets and anti-tumor drugs,and the reported number of ADRs induced by anti-tumor drugs showed an increasing trend year by year.Among the ADR reports of 1 971 cases,the report type was mainly"general"(1 442 cases,73.16%),but the reports of"serious"type involved 529 cases(26.84%);the involved organs and systems of serious ADRs(529 cases)mainly included the immune system(136 cases,25.71%),digestive system(113 cases,21.36%),skin and its appendages(93 cases,18.58%)and circulatory system(93 cases,18.58%).The main consequences of serious ADRs included"leading to hospitalization or prolonged hospitalization"(268 cases,50.66%)and"leading to other important medical events"(223 cases,42.16%),but there were 35 cases(6.62%)that endangered patients'lives.Conclusion:The middle-aged and elderly individuals are the high-risk group for ADRs,and the incidence of serious ADRs is relatively high.Therefore,it is required to continuously strengthen the medication education and monitoring in clinical practice to ensure that patients can be treated as soon as possible once ADRs occur and guarantee their safe medication.

adverse drug reactionsclinical characteristicsrational use of drugs

徐诗雨、卿爽

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苏州大学附属第一医院药学部,江苏 苏州 215006

药物不良反应 临床特点 合理用药

2024

10.13493/j.issn.1672-7878.2024.10-006

抗感染药学
江苏省苏州市第五人民医院

抗感染药学

影响因子：0.505
ISSN：1672-7878
年,卷(期)：2024.21(10)