Analysis of Correlation between Detection Rate of Methicillin-resistant Staphylococcus Aureus and Antibiotics Use Density in Inpatient Wards of a Hospital from 2012 to 2021
Objective:To analyze the correlation between the detection rate of methicillin-resistant Staphylococcus aureus(MRSA)and the antibiotics use density(AUD)in inpatient wards of a hospital from 2012 to 2021,and provide reference for the prevention and control of antimicrobial resistance and the rational use of antibacterial drugs.Methods:The etiological results and antibacterial drug use data of specimens sent from inpatient wards of Yulin First People's Hospital from January 2012 to December 2021 were selected as research data.The detection data of Gram-positive bacteria and Staphylococcus aureus(SA)and the resistance rates of SA to various antibacterial drugs were statistically analyzed,the AUD of each antibacterial drug over the years was calculated,and the correlation between the detection rate of MRSA and the AUD was analyzed.Results:From 2012 to 2021,the detection rates of SA in Gram-positive bacteria in inpatient wards of the hospital increased from 26.70%to 50.70%,with a significant change(P<0.01);the detection rates of MRSA in SA fluctuated between 38.20%and 57.04%,with an average detection rate of 48.27%.The drug susceptibility test results showed that the resistance rates of SA against ciprofloxacin,compound sulfamethoxazole,erythromycin,clindamycin,tetracycline,and gentamicin decreased year by year,with significant changes(P<0.01).In addition,the resistance rates of SA against vancomycin and linezolid were always 0.00%.From 2012 to 2021,the AUDs of penicillin,cefazolin,erythromycin,clindamycin,levofloxacin and total quinolones showed a decreasing trend(P<0.05),while the AUDs of ampicillin-sulbactam sodium,piperacillin-tazobactam sodium,vancomycin,linezolid,tigecycline and moxifloxacin showed an increasing trend(P<0.05).The correlation analysis showed that the detection rate of MRSA was positively correlated with the AUDs of penicillin,cefuroxime,erythromycin,azithromycin,levofloxacin and total quinolones(P<0.05)and negatively correlated with the AUDs of ampicillin-sulbactam sodium,ciprofloxacin,vancomycin,linezolid and tigecycline(P<0.05).The linear regression analysis results showed that the coefficient of determination R2 of the correlation between the detection rate of MRSA and the AUDs of azithromycin,levofloxacin,ciprofloxacin and total quinolones was greater than 0.7,which was clinically significant.Conclusion:The detection rates of MRSA in the hospital maintain at a high level all year round and are closely related to the use of azithromycin,levofloxacin,ciprofloxacin and total quinolones.Therefore,the use habits of such highly correlated drugs should be adjusted appropriately during clinical anti-infection treatment to reduce the occurrence of MRSA.
methicillin-resistant Staphylococcus aureusantibiotics use densitycorrelationrational use of drugs
万方数据
维普
