Research progress of ischemia-free organ transplantation
Ischemia-reperfusion injury(IRI)is a congenital defect of organ transplantation.Extended criteria donor(ECD)organs are more susceptible to IRI,resulting in a serious contradiction between supply and demand.Although the breakthrough of machine perfusion technology has brought the hope of alleviating IRI,it still cannot eradicate the organ damage caused by IRI.Ischemia-free organ transplantation can completely avoid IRI,improve graft function,improve the prognosis of patients,and expand the source of graft.This article summarizes the latest progress of ischemia-free organ transplantation,and looks forward to the future development of ischemia-free organ transplantation,so as to help researchers and clinicians in related fields understand the latest research status of ischemia-free organ transplantation and provide reference.
ischemia-free organ transplantation(IFOT)normothermic machine perfusion(NMP)ischemia reperfusion injuryearly allograft dysfunction
NETL
NSTL
万方数据
