Protective mechanism of probiotic supplements on oxidative stress levels in high-level athletes
Oxidative stress is an important mechanism of cell aging and injury,and extensive exercise can cause oxidative stress damage to cells of multiple systems/organs in body.Probiotic supplements have many biological functions,such as antioxidant and immune regulation.This study focuses on high-level athletes,aiming to clarify the protective effect of probiotic supplements on exercise-related oxidative stress damage,by analyzing the impact of probiotic supplements on oxidative stress,inflammation levels,and immune state.Oxidative stress indicators are serum malondialdehyde(MDA),superoxide dismutase(SOD),reduced glutathione(GSH),and total antioxidant capacity(TAOC);Inflammatory markers include serum C-reactive protein(CRP)and tumor necrosis factor-α(TNF)-α,and the level of interleukin-6(IL-6);Immune indicators include peripheral blood CD4+,CD8+,and CD4+CD25+T cell counts.The results showed that probiotic supplements can increase the levels of SOD,GSH,TAOC,CD4+CD25+T cell counts,and reduce the levels of MDA,TNF-α,CD4+,and CD8+cell counts,indicating that probiotic supplements can improve the oxidative stress and inflammation caused by extensive exercise,and improve immune regulatory functions.
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