GSH是调控LPS引起细胞死亡的关键物质
GSH:A Key Regulator of LPS-Induced Cell Death
胡奎 1黄英荷 1郭静娜 1曾捷敏 1邵云昊 1许少琼 1陈丹纯 1梁楚华 1吴斌华 2莫坚 1莫桂熙1
作者信息
- 1. 广东医科大学附属医院,广东 湛江 524023
- 2. 广东医科大学附属医院,广东 湛江 524023;广东湛江海洋生物医药研究所,广东 湛江 524023;南方海洋科学与工程广东实验室(湛江),广东 湛江 524023
- 折叠
摘要
LPS侵入机体后,会引起机体全身炎症反应,进而加重机体细胞的死亡.研究表明LPS可引起机体细胞出现铁死亡、凋亡、坏死和自噬,这些细胞死亡方式或许是并存的,这进一步加重了器官脏器的损伤.研究发现,在这些细胞死亡发生时,细胞内GSH水平也出现明显的变化,在逆转细胞死亡后,GSH也随其发生变化,这说明引起细胞死亡的根本原因在于细胞内氧化应激的发生,GSH作为细胞内最关键的抗氧化物质之一,在抗氧化应激方面发挥着重要作用.有研究表明,外源性的提供GSH以提升细胞内的GSH水平时,可以达到逆转细胞死亡的目的.故细胞内的GSH可成为LPS引起机体细胞死亡的关键调控物质.
Abstract
Lipopolysaccharide(LPS)invasion causes a systemic inflammatory response in the organism,which in turn exacerbates cell death in the organism.It has been shown that LPS can induce ferroptosis,apoptosis,necrosis and autophagy in the cells of the organism,and that these modes of cell death may co-exist,further exacerbating organ and tissue damage.It was found that significant changes in intracellular glutathione(GSH)levels also oc-curred when these cell deaths occurred,and the changes in the leves of GSH followed the reversal of cell death,suggesting that the underlying cause of cell death lies in the occurrence of intracellular oxidative stress,and that GSH,as one of the most critical intracellular antioxidants,plays an important role in fighting oxidative stress.It has been shown that exogenous administration of GSH to increase intracellular GSH levels can achieve the goal of reversing cell death.Therefore,intracellular GSH is a key regulator of LPS-induced cell death in the organism.
关键词
谷胱甘肽/细胞死亡/脂多糖Key words
glutathione/cell death/LPS引用本文复制引用
基金项目
Zhanjiang(China)Disease Control General Project Thematic Project Fund(2022A01157)
Fund of Southern Marine Science and Engineering Guangdong Laboratory(Zhanjiang)(ZJW-2019-007)
Science and Technology Development Special Fund Competitive Allocation Project of Zhanjiang(2021A05050)
出版年
2024
NETL
NSTL
维普
万方数据