The Impact of PCOS on the Rate of Aneuploidy and Developmental Potential of Embryos
This study investigates the impact of abnormal endocrine levels in patients with polycystic ovary syn-drome(PCOS)on the rate of embryo chromosomal aneuploidy and the final pregnancy outcome.A total of 261 treatment cycles undergoing preimplantation genetic testing at Xuzhou Maternal and Child Health Hospital from January 2019 to April 2023 were analyzed.The differences in age,infertility years,BMI,FSH,LH,E2,P,AMH,T,AFC,dosage of gonadotropin,duration of gonadotropin use and E2 level on HCG day were compared between PCOS group and non-PCOS group.Meanwhile,other influence factors,such as the 2PN rate,Day 3 high-quali-ty embryo rate,Day5/Day6 blastocyst formation rate,available blastocyst euploidy rate,available blastocyst aneu-ploidy rate and the number of biopsy per cycle of the two groups,as well as the clinical pregnancy outcome after FET of euploidy blastocysts,etc.were analyzed.There were not obvious differences of PCOS group in age,infertil-ity years,BMI,FSH,E2,P,T,the dosage of gonadotropin and days of ovarian stimulation from non-PCOS group(P＞0.05).Nonetheless,LH,AMH and E2 levels in HCG days as well as AFC(P＜0.01)were significantly higher than those in non-PCOS.The 2PN rate,Day 3 high-quality embryo rate,Day5/Day6 blastocyst forma-tion rate,available blastocyst euploidy rate and available blastocyst aneuploidy of PCOS patients were 77.67%,50.64%,53.29%,57.14%and 34.40%,respectively.It was shown that no statistical differences in above datas of PCOS compared with non-PCOS group(P＞0.05),but the number of biopsy per cycle(5.44)was higher than that in the non-PCOS group(2.64).After transferring a high proportion of day 5 high-quality euploid blastocysts(76.67%)in PCOS patients,the clinical pregnancy rate,implantation rate,miscarriage rate,and live birth rate were 78.33%,78.33%,5.00%,and 58.33%,respectively,with no statistically significant difference compared to non-PCOS patients(P＞0.05).PCOS does not significantly increase the rate of blastocyst chromo-somal aneuploidy in infertile patients.The clinical pregnancy rate,implantation rate,miscarriage rate,and live birth rate after the transfer of euploid blastocysts are not statistically different from those in the non-PCOS group,therefore,obtaining an adequate number of high-quality blastocysts for transfer is crucial for achieving fa-vorable pregnancy outcomes in PCOS patients.
NETL
NSTL
万方数据
维普
