噬菌体治疗骨科细菌感染的研究进展
Progress in Treatment of Bacterial Infections of Orthopedic with Phage Therapy
季秀玲 1李乔红 2吴颖 3李海燕1
作者信息
- 1. 昆明理工大学基础医学院,云南昆明 650500
- 2. 云南省第一人民医院急诊创伤外科,云南昆明 650032
- 3. 云南省第一人民医院皮肤科,云南昆明 650032
- 折叠
摘要
抗生素在治疗感染性疾病中扮演重要角色,但随着抗生素药物长期过度地使用及误用,导致了全球抗生素耐药性危机,为临床感染治疗带来了挑战.高度的宿主特异性、高杀菌活性及良好的生物安全性,使得感染细菌的病毒——噬菌体成为一种天然的替代抗生素的抗菌剂,噬菌体对抗多重耐药菌的特性引起了人们的广泛关注.感染是骨科手术中严重的并发症之一,骨科感染导致患者发病率和医疗费用显著增加.通过概述噬菌体治疗的优势、噬菌体治疗在骨科感染疾病中的应用以及噬菌体治疗面临的挑战,为骨科感染疾病的辅助新疗法——噬菌体治疗提供一个新的视角.
Abstract
Antibiotics play an important role in treating bacterial infections.However,with the long-term ex-cessive use and misuse of antibiotic drugs,the global antibiotic resistance crisis has been caused,which brings challenges to clinical infection treatment.Due to host specificity,high bactericidal activity,and excellent bio-safety,bacteriophages become a natural antibiotic alternative antibacterial agent.Bacteriophages against multire-sistant bacteria attracted people's attention.Infection is one of the serious complications in orthopedic surgery,which causes significant increases in patient morbidity and medical costs.We aim to provide a new perspective on bacteriophage therapy in orthopedic infections by summarizing the advantages of bacteriophage therapy,the application of bacteriophage therapy in orthopedic infections,and the challenges of bacteriophage therapy.
关键词
噬菌体/感染/植入物/骨髓炎/关节假体周围感染Key words
bacteriophages/infections/implants/osteomyelitis/periprosthetic joint infection引用本文复制引用
基金项目
国家自然科学基金项目(32160294)
云南省兴滇英才支持计划青年人才专项(YNWR-QNBJ-2019-202)
出版年
2024
NETL
NSTL
万方数据