跨胚层细胞间信号调控牙齿发育的研究进展
Research progress on cross-dermal intercellular signaling regulation of tooth development
张仲 1袁泉1
作者信息
- 1. 口腔疾病防治研究全国重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院,四川 成都 610041
- 折叠
摘要
跨胚层的细胞间相互作用在细胞分化与器官发生中发挥关键作用.从牙齿的模式形成、形态发生到功能分化等各个阶段,均有多种跨胚层生长和分化信号分子的参与.近年来,随着单细胞转录组测序技术(scRNA-seq)的应用,一些独特的细胞亚群和跨胚层的细胞间互作被报道,推动了牙齿发育的深入研究.本文综述了近年来通过使用scRNA-seq研究牙齿发育过程的新发现,并重点针对跨胚层细胞间信号的新进展进行阐述.
Abstract
The cross-dermal interaction and secretion of related signaling molecules drived cell differentiation and organogenesis.From pattern formation,morphogenesis,to functional differentiation of teeth,various cross-dermal signaling molecules were involved.In recent years,with the application of novel technologies such as single-cell transcription profiling,some unique cell subpopulations and intercellular interactions have been reported,promoting further research on tooth development.This article reviews new findings in the use of single-cell transcriptome sequencing to study tooth development processes in recent years,with a focus on advances in cross-dermal intercellular signaling.
关键词
单细胞转录组测序/牙齿发育/信号分子/干细胞Key words
single-cell RNA sequencing/tooth development/signaling molecules/stem cell引用本文复制引用
出版年
2024
NETL
NSTL
万方数据