lncRNA调控牙周炎组织中牙周膜干细胞生物学行为的研究进展
Progress in studies on lncRNA mediating the biological behavior of periodontal ligament stem cells in periodontitis tissues
徐珺怡 1王敏 1陈靓雯1
作者信息
- 1. 武汉大学口腔医院口腔种植科,湖北 武汉 430079
- 折叠
摘要
近年来,牙周炎中的长链非编码RNA(lncRNA)的多项研究表明,lncRNA在表观遗传水平、转录和转录后水平等多个层面上发挥关键作用,广泛参与牙周膜干细胞(PDLSCs)的增殖、免疫炎症反应、多项分化等生物学行为.大量lncRNA在健康牙周组织和受牙周炎影响的组织中表达有差异,lncRNA的差异性表达与PDLSCs的异常生物学行为紧密相关.本文就lncRNA调控牙周炎组织中PDLSCs生物学行为的机制作一综述.
Abstract
In recent years,several studies have shown that long non-coding RNA(lncRNA)plays crucial roles at multiple levels,such as epigenetic level,transcriptional and post-transcriptional levels.lncRNA is extensively involved in the biological behavior of per-iodontal ligament stem cells(PDLSCs),including proliferation,inflammatory immune response,and multidirectional differentiation.A great number of lncRNAs are significantly differentially expressed in healthy periodontal tissues and tissues affected by periodontitis,and the differential expression of lncRNAs is closely related to the abnormal biological behavior of PDLSCs.This paper reviews the mechanisms by which lncRNA regulates the biological behavior of PDLSCs affected by periodontitis.
关键词
长链非编码RNA/牙周炎/牙周膜干细胞Key words
long non-coding RNA/periodontitis/periodontal ligament stem cell引用本文复制引用
基金项目
湖北省自然科学基金(2021CFB147)
出版年
2024
NETL
NSTL
万方数据