Study on the role of hsa_circ_0030042 in oral squamous cell carcinoma
Objective:To identify the role of hsa_circ_0030042 in oral squamous cell carcinoma(OSCC).Methods:The expres-sion of hsa_circ_0030042 in OSCC cells was detected by qRT-PCR.Transfection of small interfering RNA(siRNA)was performed in OSCC cells to knock down hsa_circ_0030042.The effect of hsa_circ_0030042 on OSCC was validated using CCK-8 assay,colony for-mation assay,cell scratch assay and Transwell assay.Results:The expression of hsa_circ_0030042 in CAL27 and HSC3 cells was sig-nificantly increased(P＜0.001).Compared with the control group,the proliferation of CAL27 and HSC3 cells was significantly de-creased after knockdown of hsa_circ_0030042(P＜0.05).The migration and invasion ability of CAL27 and HSC3 cells were both sig-nificantly decreased(P＜0.05).Conclusions:Hsa_circ_0030042 is significantly upregulated in OSCC and can promote proliferation,invasion and migration in OSCC.
万方数据
维普
