摘要
炎症状态下牙周组织的代谢增强、微循环障碍及牙周细菌的大量繁殖所引起的牙周袋内低氧微环境是牙周炎的重要病理生理学特征.高原居住、阻塞性睡眠呼吸暂停综合征、吸烟等所引起的牙周组织及牙周袋内低氧也是牙周炎发生发展的重要危险因素.低氧与牙周炎之间的相互作用,促进着牙周炎的发生发展.本文对低氧与牙周炎的相互作用以及基于牙周袋内低氧微环境的治疗策略的最新研究进展进行综述,为牙周炎的防治提供借鉴.
Abstract
Enhanced metabolism of periodontal tissues,microcirculatory disturbances,and proliferation of periodontal bacteria within periodontal pockets resulting in a hypoxic microenvironment are significant pathophysiological features of periodontitis.Important risk factors for the occurrence and progression of periodontitis include high-altitude residence,obstructive sleep apnea syndrome,smok-ing,which induce low oxygen levels in periodontal tissues and periodontal pockets.The interaction between hypoxia and periodontitis promotes the occurrence and development of periodontitis.This review explores the interaction between hypoxia and periodontitis,as well as the latest research progress on treatment strategies based on the hypoxic microenvironment within periodontal pockets,providing insights for the prevention and treatment of periodontitis.
基金项目
国家自然科学基金(32271415)
国家自然科学基金(81970968)
国家重点研发计划(2022YFA1104400)
国家重点研发计划(2017YFA0104800)
四川省自然科学基金项目(2023NSFSC0561)
四川省自然科学基金项目(2022NSFSC1540)
四川省科技支撑项目(2022-YFS0283)
维普
万方数据