Tooth loss is one of the most common diseases,and the existing clinical restorative methods fail to achieve functional tooth regeneration.With the advancement of regenerative medicine,stem cell-based tissue engineering techniques have emerged as promising therapeutic strategies.The tooth root is the basis for the stable function of the tooth.Therefore,a key challenge in tooth re-generation lies in the successful regeneration of functional tooth roots.By collecting tissues in vitro to obtain stem cells with high prolif-eration and differentiation potential,and combining them with biocompatible scaffold materials,it is possible to construct tissue-engi-neered biological tooth roots(bio-root).This review aims to provide an overview of recent advancements in the research on bio-root.
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