Objective To investigate the expression of specific sequence AT protein 2( SATB2) ,NANOG,octamer-binding transcrip-tion factor(OCT4) in oral squamous cell carcinoma (OSCC) and its relationship with clinical pathological characteristics of oral squa-mous cell carcinoma.Methods Immunohistochemistry was used to examine the expression of SATB2,NANOG and OCT4 in oral squa-mous cell carcinoma and normal oral mucosa.Results The expressions of SATB2,NANOG and OCT4 were higher in OSCC than in normal oral mucosa,and the difference was statistically significant (P>0.05).The expression of SATB2,NANOG and OCT4 protein was unrelated with tumor grade,clinical stage,neck lymph-node metastasis(P>0.05),and the expression of SATB2,OCT4 protein was unrelated with local invasion (P>0.05).The expression of NANOG protein was related with local invasion (P<0.05).Conclusions SATB2,NANOG and OCT4 were highly expressed in oral squamous carcinoma tissues,which could be a tumor marker and used as targets of treatment.The expression of NANOG was associated with tumor invasion ability; it may play an important role in promoting the invasion and metastasis of OSCC.
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