首页|中性粒细胞与牙周炎关系的研究进展

中性粒细胞与牙周炎关系的研究进展

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牙周炎是一种常见的口腔慢性炎症,宿主因素是其致病机制之一.作为数目最多的免疫细胞,中性粒细胞可影响牙周免疫稳态,其数量或功能改变可通过多种机制加重牙周炎症,基于中性粒细胞的牙周炎干预措施在动物实验中展现出较好的牙周炎治疗前景.本文综述了中性粒细胞在牙周炎中作用的研究进展,并总结展望目前靶向中性粒细胞的治疗手段,以期为牙周炎防治提供新的视角.
Role of neutrophil in periodontitis:An updated review
Periodontitis is a prevalent and persisting oral inflammation,during which host factors are critically involved.As the most abundant immune cells,neutrophils actively partake in periodontal homeostasis,the alteration of neutrophil number or function could aggravate periodontitis through multifaceted mechanisms.Additionally,neutrophil-targeted therapies showed promising effects on treating periodontitis in animal trials.In this paper,research progress of neutrophil's role in periodontitis and immunomodulation on neutrophil were reviewed in order to provide new perspectives for periodontitis treatment.

neutrophilperiodontitisneutrophil-modulating treatment

王雪奎、孙瑶

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同济大学附属口腔医院种植科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,上海(200072)

中性粒细胞 牙周炎 免疫治疗

国家自然科学基金

82270963

2024

口腔医学
南京医科大学口腔医学院

口腔医学

CSTPCD
影响因子:0.641
ISSN:1003-9872
年,卷(期):2024.44(4)
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