首页|基于CBCT三维形态分析的中国青少年颈椎骨成熟度定量方法研究

基于CBCT三维形态分析的中国青少年颈椎骨成熟度定量方法研究

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目的 通过锥形束CT(CBCT)影像探究颈椎三维形态与骨骼成熟度之间的相关性,并建立基于颈椎三维形态的颈椎骨成熟度(CVM)定量评估模型.方法 共收集 358 例(男 175 例,女 183 例)中国青少年患者的颅颌面CBCT影像,随机分为模型建立组(277 例)及验证组(81 例).定义并测量了 21 个颈椎三维形态学参数,纳入颈椎全部部位,包括颈椎椎体、横突、棘突、椎弓根、锥板、关节突.颈椎骨成熟指数(CVMI)由有经验的正畸医师测定并作为参考标准.采用Spearman等级相关系数和多元线性逐步分析确定相关性并构建回归模型.使用验证组数据检验各模型的评估可靠性并应用配对样本Wilcoxon符号秩检验比较模型评估值与参考标准.结果 颈椎各部位的三维形态学变化与CVMI相关(P＜0.05).男性和女性模型各包括 6 个三维形态参数,其中 3 个相同.男性模型和女性模型校正R2 分别为 0.899 和 0.902,评估准确率分别为85.0%和 85.4%.配对样本Wilcoxon符号秩检验结果显示两个回归模型与参考标准间均无统计学差异(P＞0.05).结论 颈椎三维形态与骨骼成熟度相关,本研究建立的CVM三维形态学评估方法及相应的回归模型具有良好的可信度,与专家的一致性较高.
Quantitative analysis of cervical vertebral maturation in Chinese adolescents based on three-dimensional morphology of cervi-cal vertebrae
Objective To investigate associations between three-dimensional(3D)morphology of cervical vertebrae and skeletal mat-uration by cone-beam computed tomography(CBCT)and establish corresponding regression models for quantitatively evaluating cervical vertebral maturation(CVM).Methods The analyzed sample consisted of 358 CBCT images(175 male,183 female),of which 277 images were randomly selected as the model development group and 81 as the performance test group.Twenty-one 3D morphological pa-rameters were defined and measured,incorporating all parts of the cervical vertebrae,including the cervical vertebral bodies,transverse processes,spinous processes,pedicles,lamina,and articular processes.The cervical vertebral maturation index(CVMI)was determined by experienced orthodontists as reference standard.Spearman's rank correlation coefficient and multivariable stepwise regression analysis were used to identify the associations and build regression models.The performance test group was employed to ex-amine each model's reliability.Paired-samples Wilcoxon signed-rank test compared the CVMI of the model prediction with the reference standard.Results Three-dimensional morphological changes in various parts of the cervical vertebrae correlated with CVMI(P＜0.05).Six 3D morphometric parameters were each recognized for male and female models,three of which were identical.The adjusted R2 was 0.899 for males and 0.902 for females,with corresponding accuracies of 85.0%and 85.4%,respectively.These models showed no difference as compared with the reference standard(P＞0.05).Con-clusion New associations were found between 3D morphology of cer-vical vertebrae and skeletal maturation.The 3D-driven morphometric CVM assessment method and corresponding regression models exhibited good credibility and high consistency with experts.

skeletal maturationcervical vertebrae maturation indexthree-dimensional morphologycone-beam computed tomo-graphy

吴玥、唐雯、张语嫣然、袁玮煜、潘逸菲、陈新宇、徐海洋、吕云帆、IZADIKHAH Iman、曹丹、谢理哲、严斌

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南京医科大学附属口腔医院正畸科,口腔疾病研究与防治国家级重点实验室培育建设点(南京医科大学),江苏省口腔转化医学工程研究中心,江苏南京(210029)

骨骼成熟度 颈椎骨成熟指数 三维形态 CBCT

国家自然科学基金国家自然科学基金国家重点研发计划江苏省卫生健康委医学科研重点项目江苏省重点研发计划江苏省科技厅社会发展面上项目

82071143821010792022YFC2402103ZDA2020003BE2022795BE2023836

2024

10.13591/j.cnki.kqyx.2024.05.001

口腔医学
南京医科大学口腔医学院

口腔医学

CSTPCD
影响因子：0.641
ISSN：1003-9872
年,卷(期)：2024.44(5)
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