牙髓干细胞治疗糖尿病的研究进展
Progress and prospects of dental pulp stem cells in diabetes treatment
黄蔼岚 1郭培培 1陆晓庆 2吴锦涛 3李泽汉 3徐秀清 3王娟 3周莉丽3
作者信息
- 1. 南京医科大学口腔医学院口腔内科学系,江苏南京(210029)
- 2. 南京医科大学附属口腔医院教学办公室,江苏省口腔转化医学工程研究中心,江苏南京(210029)
- 3. 南京医科大学附属口腔医院牙体牙髓病科,江苏省口腔疾病研究重点实验室,江苏省口腔转化医学工程研究中心,江苏南京(210029)
- 折叠
摘要
糖尿病(diabetes mellitus,DM)是一种以高血糖为主要特征的慢性代谢性疾病,由胰岛素抵抗或胰岛素分泌异常引起,因胰岛β细胞的破坏导致患者持续高血糖,可诱导多发性神经病变等并发症,患病率与死亡率均较高.牙髓干细胞(dental pulp stem cells,DPSCs)获取容易,具有自我更新、多向分化及高度增殖的能力,可被诱导分化为胰岛β细胞参与胰岛素分泌和免疫调节,在慢性疾病的治疗中取得了一定成果.此外,DPSCs还可通过抑制自身免疫、调节炎症及抗氧化应激等途径改善 1 型糖尿病患者症状.本文综述了DPSCs的生物学特性并探究其通过对DM及其并发症治疗不同机制,以期完善DM管理.
Abstract
Diabetes mellitus(DM)stands as a chronic metabolic ailment predominantly characterized by elevated blood glucose lev-els,stemming from either a resistance to insulin or aberrations in insulin secretion.The ensuing persistent hyperglycemia,a direct con-sequence of pancreatic β-cell devastation,acts as a catalyst for a myriad of complications,inclusive of extensive neuropathies.The dis-ease has substantial prevalence and mortality rates,underscoring the gravity of its impact on public health.Dental pulp stem cells(DPSCs)are readily obtainable,and they exhibit a profound capacity for self-renewal,multi-lineage differentiation,and vigorous pro-liferation.Remarkably,DPSCs can differentiate into pancreatic β-cells,subsequently participate in insulin secretion and play a pivotal role in immune modulation.This has achieved notable advancements in the therapeutic domain,particularly in the treatment of chronic diseases.Furthermore,DPSCs harbor the potential to mitigate symptoms in patients afflicted with type 1 diabetes.They navigate this therapeutic pathway through mechanisms that involve suppressing autoimmunity,modulating inflammatory responses,and counteracting oxidative stress.This article meticulously reviews the biological characteristics inherent to DPSCs and explores their multifaceted thera-peutic potential in addressing DM and its associated complications.Through this endeavor,the article aims to contribute to the refine-ment and enhancement of DM management strategies.
关键词
牙髓干细胞/糖尿病/胰岛素/并发症/免疫调节Key words
dental pulp stem cells/diabetes mellitus/insulin/complication/immunoregulation引用本文复制引用
基金项目
国家自然科学基金(82201024)
中华口腔医学会青年科研基金树脂材料研究项目(CSA-R2018-10)
出版年
2024
NETL
NSTL
万方数据