Lysophosphatidic acid(LPA),a simple bioactive lysophospholipid widely dispersed in human body,has been reported to regulate the proliferation,chemotaxis and differentiation of multiple cells and further participate in various developmental and patho-physiological processes through at least six specific G protein-coupled receptors(GPCRs),LPA1-LPA6.Recently,the possibility of targeting LPA or LPA receptors in bone remodeling has been heatedly discussed.On the one hand,LPA modulate the activities of bone-related cells directly.On the other hand,LPA might be the potential regulator that links the nervous-vascular-immune-skeletal systems,which could provide a good microenvironment for bone remodeling and further promote bone regeneration.Thus,this review summarizes recent studies on the effects and application prospect of LPA on bone remodeling.
NETL
NSTL
万方数据
