溶血磷脂酸调控骨改建作用的研究进展
Advances in lysophosphatidic acid for bone remodeling
张勤 1向琳 2宫苹2
作者信息
- 1. 南京大学医学院附属口腔医院种植科,南京市口腔医院,南京大学口腔医学研究所,江苏南京(210008)
- 2. 口腔疾病研究全国重点实验室,国家口腔医学中心,国家口腔疾病临床医学研究中心,四川大学华西口腔医院种植科,四川成都(610041)
- 折叠
摘要
溶血磷脂酸(lysophosphatidic acid,LPA)是机体内天然存在的一种小分子甘油磷脂.其在人体内分布广泛,与其受体LPA 1-6结合后,经复杂的下游信号转导机制,介导细胞增殖、迁移等多种细胞学行为,进而参与肿瘤发生发展、炎症、创伤愈合等生物学过程.近年来,LPA在调控骨代谢方面的作用受到越来越多的关注.它一方面可以直接作用于骨相关细胞,另一方面可以作为骨组织中神经-血管-免疫-骨的潜在交联因子,为骨改建提供良好的微环境,进一步影响骨再生.该文就溶血磷脂酸调控骨代谢作用的研究进展作一综述.
Abstract
Lysophosphatidic acid(LPA),a simple bioactive lysophospholipid widely dispersed in human body,has been reported to regulate the proliferation,chemotaxis and differentiation of multiple cells and further participate in various developmental and patho-physiological processes through at least six specific G protein-coupled receptors(GPCRs),LPA1-LPA6.Recently,the possibility of targeting LPA or LPA receptors in bone remodeling has been heatedly discussed.On the one hand,LPA modulate the activities of bone-related cells directly.On the other hand,LPA might be the potential regulator that links the nervous-vascular-immune-skeletal systems,which could provide a good microenvironment for bone remodeling and further promote bone regeneration.Thus,this review summarizes recent studies on the effects and application prospect of LPA on bone remodeling.
关键词
溶血磷脂酸/骨改建/G蛋白偶联受体Key words
lysophosphatidic acid/bone remodeling/G-proteincoupledreceptor引用本文复制引用
基金项目
国家自然科学基金(82170997)
国家自然科学基金(82170935)
出版年
2024
NETL
NSTL
万方数据