摘要
脂代谢重编程对头颈鳞癌发生发展、转移、耐药性形成至关重要.多种脂代谢关键酶在头颈鳞癌中表达上调,与癌症放化疗抵抗、预后不良密切相关.该文主要阐述头颈鳞癌中脂代谢的改变,从脂肪酸从头合成、脂肪酸氧化、甘油磷脂代谢以及甲羟戊酸与胆固醇合成途径四方面着手,探究脂代谢相关酶在头颈鳞癌中的表达异常及临床相关性、其对头颈鳞癌治疗耐药的影响及可能机制、已有的及潜在的靶向治疗策略.调整膳食结构辅助、多靶点联合用药、多种治疗方法联用可能是未来调控脂代谢、减少耐药、提高抗癌疗效的可行性策略.
Abstract
The reprogramming of lipid metabolism is a significant factor influencing various aspects of head and neck squamous cell carcinoma,including its occurrence,development,metastasis,and resistance to radio-chemotherapy.There is a considerable elevation in the expression levels of enzymes and genes related to lipid metabolism in tumor tissues compared to normal tissues.This up-regulation is associated with both treatment resistance and a poor prognosis.This review focuses mainly on alterations in lipid metabolism in head and neck squamous cell carcinoma.It systematically explores the atypical expression and clinical significance of lipid metabolism-related enzymes,evaluates their influence on treatment resistance,elucidates the underlying mechanisms of this resistance,and discus-ses current and potential targeted therapeutic approaches.The comprehensive analysis comprises four pivotal aspects:de novo lipogene-sis,fatty acid oxidation,glycerophospholipids metabolism,and mevalonate and cholesterol synthesis pathways.Feasible strategies,such as the adjustment of dietary structure,the administration of multi-target drugs,and the utilization of combination treatment thera-pies,are deliberated as potential interventions to modulate lipid metabolism,reverse treatment resistance,and enhance the efficacy of anti-cancer treatments.
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