头颈部恶性肿瘤是全球范围内的第七大常见肿瘤,约占全部恶性肿瘤的 10%,放射治疗是头颈部恶性肿瘤的重要治疗方案.放射性颌骨坏死(osteoradionecrosis of the jaws,ORNJ)是一种头颈部恶性肿瘤放疗后出现的难治并发症,常表现出颌骨坏死和软组织暴露.当前ORNJ的发病机制尚未完全明确,其治疗仍具有挑战性.该病传统的治疗方式为部分切除坏死颌骨结合骨皮瓣重建.但近年来,一些新技术、新思路被用于治疗该疾病,对于程度较轻的放射性颌骨坏死,治疗理念趋于保守.本文主要归纳国内外最新研究进展,对放射性颌骨坏死的发病机制、临床表现和治疗策略进行综述.
Research progress of treatment strategies for osteoradionecrosis of the jaws
Head and neck cancer is the seventh most common cancer in the world,accounting for about 10%of all malignant tumors.Radiotherapy is an important treatment for head and neck cancer.Osteonecrosis of the jaws(ORNJ)is a refractory complication after ra-diotherapy for head and neck cancer,which often manifests as osteonecrosis of the jaw and soft tissue exposure.The current pathogene-sis of ORNJ has not been fully clarified and its treatment remains challenging.The traditional treatment for this disease is partial resec-tion of necrotic jaw bone and reconstruction with osteocutaneous flap.However,in recent years,some new techniques and ideas have been used to treat the disease.For mild osteoradionecrosis of the jaw,the treatment concept tends to be conservative.This article mainly summarizes the latest research progress at home and abroad,and reviews the pathogenesis,clinical manifestations and treatment strate-gies for osteoradionecrosis of the jaws.
osteonecrosis of the jawsmesenchymal stem cellsvirtual surgical planning
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