Expression of Hypoxia Inducible Factor-1α in Periodontal Tissues of Diabetic Patients with Periodontitis and Its Rela-tionship with Gingival Microcirculation Disorder
Objective:To investigate the expression characteristics of hypoxia inducible factor-1α(HIF-1α)in peri-odontal tissues of diabetic patients with periodontitis and the relationship between HIF-1α and gingival microcircula-tion parameters.Methods:A total of 237 patients with type 2 diabetes who were treated in our hospital from March 2019 to March 2022 were selected as the study objects.According to whether the patients had periodontitis or not,they were divided into the group with periodontitis(105 cases)and the group without periodontitis(132 cases).Lo-gistic regression model was used to analyze the relationship between the expression level of HIF-1α and the risk of periodontitis in diabetic patients.The dose-response relationship between HIF-1α and periodontitis was analyzed by restricted cubic spline model.Multivariate logistic regression analysis was used to analyze the factors affecting the occurrence of periodontitis in diabetic patients.The interaction of HIF-1α and gingival microcirculation parameters was analyzed by Cox regression.The structural equation prediction model was established and verified.Results:Af-ter adjusting for confounding factors,HIF-1α was positively correlated with periodontitis in diabetic patients.The expression level of HIF-1α was not nonlinear dose-response related to diabetic patients with periodontitis,and was not related to gender.HIF-1α and gingival microcirculation parameters were important factors affecting the occur-rence of periodontitis.The interaction of HIF-1α and gingival microcirculation parameters might increase the risk of periodontitis in diabetic patients.The interaction effect of HIF-1α combined with gingival blood flow was the high-est.The overall adaptation of structural equation model was better,which could reflect the relationship between the influencing factors and the occurrence of periodontitis.The prediction model had good differentiation and independ-ence.Conclusion:HIF-1α is a risk factor for periodontitis in diabetic patients.The interaction of HIF-1α and gingival mi-crocirculation parameters may increase the risk of periodonti-tis in diabetic patients.
type 2 diabetesperiodontitishypoxia inducing factor-1αgingival microcirculationperiodon-tal tissue
万方数据
维普
