Effect of Teriparatide on Root Resorption during Orthodontic Tooth Movement in Ovariectomized Rats by Micro-CT
Objective:To investigate the effect of teriparatide on root resorption during orthodontic tooth move-ment in osteoporotic rats using micro-CT.Methods:Seventy-two female Wistar rats(8-week-old)were randomly divided into 3 groups as follows:ovariectomized group,teriparatide group(ovariectomized rats treated by teriparati-de),and the control group(sham-operated).After twelve weeks,50g of force was placed to move the first molar on the left side by using a closed-coil spring.The teriparatide group was given subcutaneous injection of teriparatide daily,while the ovariectomized group and control group were given equal amounts of PBS solution.Rats were sacri-ficed on days 0,7,14,and 21,and samples were collected and subjected to micro-CT scanning.Results:The root resorption lacunae can be observed in all groups from day 7,and the volume of the lacunae increased gradually with time.The root resorption of rats in ovariectomized group was more serious than that in control group.Teriparatide treatment could significantly reduce the root resorption of ovariectomized rats on day 21.Conclusion:Osteoporosis can aggravate root resorption during tooth movement in rats,and intermittent teriparatide administration can reduce orthodontically induced root resorption in osteoporotic rats.
万方数据
维普
