牙周炎是一种影响牙齿周围支持组织的慢性炎症性疾病.牙周组织损伤主要由宿主的免疫反应介导,而目前临床治疗牙周炎主要以局部机械清除菌斑和结石为主,免疫疗法在牙周临床中应用很少.因此,对牙周炎免疫治疗的研究就显得极其重要.巨噬细胞参与宿主免疫反应的关键环节,通过识别、吞噬和清除外来病原体和异物在牙周炎的发生、发展过程中发挥重要作用.研究表明,这一过程是通过巨噬细胞集落刺激因子-1(colony stim-ulation factor-1,CSF-1)/巨噬细胞集落刺激因子-1 受体(colony stimulation factor-1 receptor,CSF-lR)信号轴介导的巨噬细胞炎性调控、破骨细胞骨吸收调控进行的.本综述将 CSF-1/CSF-1 R 信号轴在牙周炎中的作用及其作用机制进行总结,以期为后续研究及牙周炎的免疫治疗提供依据.
Advances of Macrophage Colony-stimulating Factor-1 and Its Receptor in Periodontitis
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth.The host immune response is now recognized as the primary cause of tissue damage in periodontitis.Current clinical treat-ment mainly focuses on removing plaque and calculus mechanically,with limited use of immunotherapy.Neverthe-less,it is essential to research immunotherapy for periodontitis.Macrophages play a pivotal role in the host immune response.They recognize,phagocytose,and eliminate foreign pathogens and objects.The colony stimulation factor-1(CSF-1)/colony stimulation factor-1 receptor(CSF-1 R)pathway is involved in the progression of periodontitis by regulating macrophage inflammation and osteoclast bone resorption.Understanding the mechanism of action of CSF-1/CSF-1 R in periodontitis is essential for future studies and the development of immunotherapy approaches.
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